cellular senescence

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Inhibition of 3-phosphoinositide–dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts
Sugyun An, Si-Young Cho, Junsoo Kang, Soobeom Lee, Hyung-Su Kim, Dae-Jin Min, EuiDong Son, and Kwang-Hyun Cho

PNAS December 8, 2020 117 (49) 31535-31546; first published November 23, 2020. https://doi.org/10.1073/pnas.1920338117
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O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence
Jong-Sun Lee and Zhiguo Zhang

PNAS June 7, 2016 113 (23) E3213-E3220; first published May 23, 2016. https://doi.org/10.1073/pnas.1600509113
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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu, Tamara Tchkonia, Husheng Ding, Mikolaj Ogrodnik, Ellen R. Lubbers, Tamar Pirtskhalava, Thomas A. White, Kurt O. Johnson, Michael B. Stout, Vojtech Mezera, Nino Giorgadze, Michael D. Jensen, Nathan K. LeBrasseur, and James L. Kirkland

PNAS November 17, 2015 112 (46) E6301-E6310; first published November 2, 2015. https://doi.org/10.1073/pnas.1515386112
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Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells
Michael C. Velarde, Marco Demaria, Simon Melov, and Judith Campisi

PNAS August 18, 2015 112 (33) 10407-10412; first published August 3, 2015. https://doi.org/10.1073/pnas.1505675112
Open Access
Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources
Argita Zalli, Livia A. Carvalho, Jue Lin, Mark Hamer, Jorge D. Erusalimsky, Elizabeth H. Blackburn, and Andrew Steptoe

PNAS March 25, 2014 111 (12) 4519-4524; https://doi.org/10.1073/pnas.1322145111
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Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality
Seong-Jun Cho, Andrea Rossi, Yong-Sam Jung, Wensheng Yan, Gang Liu, Jin Zhang, Min Zhang, and Xinbin Chen

PNAS June 4, 2013 110 (23) 9362-9367; https://doi.org/10.1073/pnas.1221242110

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