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chloride channel

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Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel
Anna K. Koster, Austin L. Reese, Yuri Kuryshev, Xianlan Wen, Keri A. McKiernan, Erin E. Gray, Caiyun Wu, John R. Huguenard, Merritt Maduke, and J. Du Bois

PNAS December 22, 2020 117 (51) 32711-32721; first published December 4, 2020. https://doi.org/10.1073/pnas.2009977117
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LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses
Ping Li, Meiqin Hu, Ce Wang, Xinghua Feng, ZhuangZhuang Zhao, Ying Yang, Nirakar Sahoo, Mingxue Gu, Yexin Yang, Shiyu Xiao, Rajan Sah, Timothy L. Cover, Janet Chou, Raif Geha, Fernando Benavides, Richard I. Hume, and Haoxing Xu

PNAS November 17, 2020 117 (46) 29155-29165; first published November 2, 2020. https://doi.org/10.1073/pnas.2016539117
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A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca²⁺-activated Cl⁻ channel ANO1 (TMEM16A)
Kuai Yu, Tao Jiang, YuanYuan Cui, Emad Tajkhorshid, and H. Criss Hartzell

PNAS October 1, 2019 116 (40) 19952-19962; first published September 12, 2019. https://doi.org/10.1073/pnas.1904012116
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Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl⁻/H⁺ antiporter
Kunwoong Park, Byoung-Cheol Lee, and Hyun-Ho Lim

PNAS August 27, 2019 116 (35) 17345-17354; first published August 13, 2019. https://doi.org/10.1073/pnas.1901822116
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A selective class of inhibitors for the CLC-Ka chloride ion channel
- From the Cover
Anna K. Koster, Chase A. P. Wood, Rhiannon Thomas-Tran, Tanmay S. Chavan, Jonas Almqvist, Kee-Hyun Choi, J. Du Bois, and Merritt Maduke

PNAS May 22, 2018 115 (21) E4900-E4909; first published April 18, 2018. https://doi.org/10.1073/pnas.1720584115
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Taming unruly chloride channel inhibitors with rational design
- May 07, 2018
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Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion
Zhixiong Xu, Gaelle M. Lefevre, Oksana Gavrilova, Mark B. Foster St. Claire, Gregory Riddick, and Gary Felsenfeld

PNAS November 25, 2014 111 (47) 16760-16765; first published November 10, 2014. https://doi.org/10.1073/pnas.1419240111
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The Cap1–claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation
Yongfeng Gong, Miao Yu, Jing Yang, Ernie Gonzales, Ronaldo Perez, Mingli Hou, Piyush Tripathi, Kathleen S. Hering-Smith, L. Lee Hamm, and Jianghui Hou

PNAS September 9, 2014 111 (36) E3766-E3774; first published August 25, 2014. https://doi.org/10.1073/pnas.1406741111
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Reconstitution of abscisic acid activation of SLAC1 anion channel by CPK6 and OST1 kinases and branched ABI1 PP2C phosphatase action
Benjamin Brandt, Dennis E. Brodsky, Shaowu Xue, Juntaro Negi, Koh Iba, Jaakko Kangasjärvi, Majid Ghassemian, Aaron B. Stephan, Honghong Hu, and Julian I. Schroeder

PNAS June 26, 2012 109 (26) 10593-10598; https://doi.org/10.1073/pnas.1116590109

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