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drug resistance

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Loss of BOP1 confers resistance to BRAF kinase inhibitors in melanoma by activating MAP kinase pathway
Romi Gupta, Suresh Bugide, Biao Wang, Michael R. Green, Douglas B. Johnson, and Narendra Wajapeyee

PNAS published ahead of print February 19, 2019. https://doi.org/10.1073/pnas.1821889116
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Microbiome as a tool and a target in the effort to address antimicrobial resistance
David A. Relman and Marc Lipsitch

PNAS December 18, 2018 115 (51) 12902-12910; published ahead of print December 18, 2018. https://doi.org/10.1073/pnas.1717163115
Open Access
Evolution of drug resistance in an antifungal-naive chronic Candida lusitaniae infection
Elora G. Demers, Amy R. Biermann, Sawyer Masonjones, Alex W. Crocker, Alix Ashare, Jason E. Stajich, and Deborah A. Hogan

PNAS November 20, 2018 115 (47) 12040-12045; published ahead of print November 2, 2018. https://doi.org/10.1073/pnas.1807698115
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Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC–β4 loop insertion mutations
Zheng Ruan and Natarajan Kannan

PNAS August 28, 2018 115 (35) E8162-E8171; published ahead of print August 13, 2018. https://doi.org/10.1073/pnas.1803152115
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Structure of the EmrE multidrug transporter and its use for inhibitor peptide design
Victor Ovchinnikov, Tracy A. Stone, Charles M. Deber, and Martin Karplus

PNAS August 21, 2018 115 (34) E7932-E7941; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1802177115
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Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors
Kristin D. Lane, Jianbing Mu, Jinghua Lu, Sean T. Windle, Anna Liu, Peter D. Sun, and Thomas E. Wellems

PNAS June 12, 2018 115 (24) 6285-6290; published ahead of print May 29, 2018. https://doi.org/10.1073/pnas.1804492115
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Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum
Rodrigo G. Ducati, Hilda A. Namanja-Magliano, Rajesh K. Harijan, J. Eduardo Fajardo, Andras Fiser, Johanna P. Daily, and Vern L. Schramm

PNAS February 27, 2018 115 (9) 2114-2119; published ahead of print February 12, 2018. https://doi.org/10.1073/pnas.1525670115
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Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer
K. L. Thu, J. Silvester, M. J. Elliott, W. Ba-alawi, M. H. Duncan, A. C. Elia, A. S. Mer, P. Smirnov, Z. Safikhani, B. Haibe-Kains, T. W. Mak, and D. W. Cescon

PNAS February 13, 2018 115 (7) E1570-E1577; published ahead of print January 29, 2018. https://doi.org/10.1073/pnas.1719577115
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Human bone perivascular niche-on-a-chip for studying metastatic colonization
Alessandro Marturano-Kruik, Michele Maria Nava, Keith Yeager, Alan Chramiec, Luke Hao, Samuel Robinson, Edward Guo, Manuela Teresa Raimondi, and Gordana Vunjak-Novakovic

PNAS February 6, 2018 115 (6) 1256-1261; published ahead of print January 23, 2018. https://doi.org/10.1073/pnas.1714282115
Open Access
Resource limitation prevents the emergence of drug resistance by intensifying within-host competition
Nina Wale, Derek G. Sim, Matthew J. Jones, Rahel Salathe, Troy Day, and Andrew F. Read

PNAS December 26, 2017 114 (52) 13774-13779; published ahead of print December 12, 2017. https://doi.org/10.1073/pnas.1715874115

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