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drug resistance

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Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro
Asiya Gusa, Jonathan D. Williams, Jang-Eun Cho, Anna Floyd Averette, Sheng Sun, Eva Mei Shouse, Joseph Heitman, J. Andrew Alspaugh, and Sue Jinks-Robertson

PNAS May 5, 2020 117 (18) 9973-9980; first published April 17, 2020. https://doi.org/10.1073/pnas.2001451117
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Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents
Grégory Thiabaud, Guangan He, Sajal Sen, Kathryn A. Shelton, Wallace B. Baze, Luke Segura, Julie Alaniz, Ruben Munoz Macias, Greg Lyness, Alan B. Watts, Hyun Min Kim, Hyunseung Lee, Mi Young Cho, Kwan Soo Hong, Rick Finch, Zahid H. Siddik, Jonathan F. Arambula, and Jonathan L. Sessler

PNAS March 31, 2020 117 (13) 7021-7029; first published March 16, 2020. https://doi.org/10.1073/pnas.1914911117
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Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy
Xiaodong Wang, Xiaohui Yang, Chang Zhang, Yang Wang, Tianyou Cheng, Liqiang Duan, Zhou Tong, Shuguang Tan, Hangjie Zhang, Phei Er Saw, Yinmin Gu, Jinhua Wang, Yibi Zhang, Lina Shang, Yajuan Liu, Siyuan Jiang, Bingxue Yan, Rong Li, Yue Yang, Jie Yu, Yunzhao Chen, George Fu Gao, Qinong Ye, and Shan Gao

PNAS March 24, 2020 117 (12) 6640-6650; first published March 11, 2020. https://doi.org/10.1073/pnas.1921445117
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Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance
Yeqi Li, Yuanwei Zhang, Chi Zhang, Hongchen Wang, Xiaolei Wei, Peiying Chen, and Ling Lu

PNAS January 21, 2020 117 (3) 1711-1721; first published December 6, 2019. https://doi.org/10.1073/pnas.1911560116
See companion article:
Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance
- Dec 06, 2019

Linking calcium signaling and mitochondrial function in fungal drug resistance
- Jan 03, 2020
Open Access
Extensive subclonal mutational diversity in human colorectal cancer and its significance
Lawrence A. Loeb, Brendan F. Kohrn, Kaitlyn J. Loubet-Senear, Yasmin J. Dunn, Eun Hyun Ahn, Jacintha N. O’Sullivan, Jesse J. Salk, Mary P. Bronner, and Robert A. Beckman

PNAS December 26, 2019 116 (52) 26863-26872; first published December 5, 2019. https://doi.org/10.1073/pnas.1910301116
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Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii
Alex Rosenberg, Madeline R. Luth, Elizabeth A. Winzeler, Michael Behnke, and L. David Sibley

PNAS December 26, 2019 116 (52) 26881-26891; first published December 5, 2019. https://doi.org/10.1073/pnas.1914732116
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Short-chain diamines are the physiological substrates of PACE family efflux pumps
Karl A. Hassan, Varsha Naidu, Jacob R. Edgerton, Karla A. Mettrick, Qi Liu, Leila Fahmy, Liping Li, Scott M. Jackson, Irshad Ahmad, David Sharples, Peter J. F. Henderson, and Ian T. Paulsen

PNAS September 3, 2019 116 (36) 18015-18020; first published August 15, 2019. https://doi.org/10.1073/pnas.1901591116
Open Access
A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1
Anastasia De Luca, Lorien J. Parker, Wee Han Ang, Carlo Rodolfo, Valentina Gabbarini, Nancy C. Hancock, Francesca Palone, Anna P. Mazzetti, Laure Menin, Craig J. Morton, Michael W. Parker, Mario Lo Bello, and Paul J. Dyson

PNAS July 9, 2019 116 (28) 13943-13951; first published June 20, 2019. https://doi.org/10.1073/pnas.1903297116
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Heterogeneity in refractory acute myeloid leukemia
Sachi Horibata, Gege Gui, Justin Lack, Christin B. DeStefano, Michael M. Gottesman, and Christopher S. Hourigan

PNAS May 21, 2019 116 (21) 10494-10503; first published May 7, 2019. https://doi.org/10.1073/pnas.1902375116
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Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle
Rachel Van Duyne, Lillian S. Kuo, Phuong Pham, Ken Fujii, and Eric O. Freed

PNAS April 30, 2019 116 (18) 9040-9049; first published April 11, 2019. https://doi.org/10.1073/pnas.1820333116

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