enzyme design

Open Access
A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase
Richard Stenner, Jack W. Steventon, Annela Seddon, and J. L. Ross Anderson

PNAS January 21, 2020 117 (3) 1419-1428; first published January 2, 2020. https://doi.org/10.1073/pnas.1915054117
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Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase
Garima Jindal, Katerina Slanska, Veselin Kolev, Jiri Damborsky, Zbynek Prokop, and Arieh Warshel

PNAS January 8, 2019 116 (2) 389-394; first published December 26, 2018. https://doi.org/10.1073/pnas.1804979115
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Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase
Rajesh K. Harijan, Ioanna Zoi, Dimitri Antoniou, Steven D. Schwartz, and Vern L. Schramm

PNAS June 20, 2017 114 (25) 6456-6461; first published June 5, 2017. https://doi.org/10.1073/pnas.1704786114
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Structural and thermodynamic consequences of burial of an artificial ion pair in the hydrophobic interior of a protein
Aaron C. Robinson, Carlos A. Castañeda, Jamie L. Schlessman, and Bertrand García-Moreno E.

PNAS August 12, 2014 111 (32) 11685-11690; first published July 29, 2014. https://doi.org/10.1073/pnas.1402900111
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Engineering a model protein cavity to catalyze the Kemp elimination
Matthew Merski and Brian K. Shoichet

PNAS October 2, 2012 109 (40) 16179-16183; https://doi.org/10.1073/pnas.1208076109

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