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enzyme mechanism

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Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction
Jianyu Zhang, Jeremy L. Balsbaugh, Shuaihua Gao, Natalie G. Ahn, and Judith P. Klinman

PNAS May 19, 2020 117 (20) 10797-10805; first published May 5, 2020. https://doi.org/10.1073/pnas.1917219117
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Mechanism of activation of the human cysteine desulfurase complex by frataxin
Shachin Patra and David P. Barondeau

PNAS September 24, 2019 116 (39) 19421-19430; first published September 11, 2019. https://doi.org/10.1073/pnas.1909535116
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Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase
Cameron L. Noland, Michele D. Kattke, Jingyu Diao, Susan L. Gloor, Homer Pantua, Mike Reichelt, Anand K. Katakam, Donghong Yan, Jing Kang, Inna Zilberleyb, Min Xu, Sharookh B. Kapadia, and Jeremy M. Murray

PNAS July 25, 2017 114 (30) E6044-E6053; first published July 11, 2017. https://doi.org/10.1073/pnas.1707813114
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Neutron structures of the Helicobacter pylori 5′-methylthioadenosine nucleosidase highlight proton sharing and protonation states
Michael T. Banco, Vidhi Mishra, Andreas Ostermann, Tobias E. Schrader, Gary B. Evans, Andrey Kovalevsky, and Donald R. Ronning

PNAS November 29, 2016 113 (48) 13756-13761; first published November 16, 2016. https://doi.org/10.1073/pnas.1609718113
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Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36
Myles B. Poulin, Jessica L. Schneck, Rosalie E. Matico, Patrick J. McDevitt, Michael J. Huddleston, Wangfang Hou, Neil W. Johnson, Sara H. Thrall, Thomas D. Meek, and Vern L. Schramm

PNAS February 2, 2016 113 (5) 1197-1201; first published January 19, 2016. https://doi.org/10.1073/pnas.1521036113
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C-S bond cleavage by a polyketide synthase domain
Ming Ma, Jeremy R. Lohman, Tao Liu, and Ben Shen

PNAS August 18, 2015 112 (33) 10359-10364; first published August 3, 2015. https://doi.org/10.1073/pnas.1508437112
Open Access
Structural basis of collagen fiber degradation by cathepsin K
Adeleke H. Aguda, Preety Panwar, Xin Du, Nham T. Nguyen, Gary D. Brayer, and Dieter Brömme

PNAS December 9, 2014 111 (49) 17474-17479; first published November 24, 2014. https://doi.org/10.1073/pnas.1414126111
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Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis
Daniel Burschowsky, André van Eerde, Mats Ökvist, Alexander Kienhöfer, Peter Kast, Donald Hilvert, and Ute Krengel

PNAS December 9, 2014 111 (49) 17516-17521; first published November 24, 2014. https://doi.org/10.1073/pnas.1408512111
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Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
Nathalie Preiswerk, Tobias Beck, Jessica D. Schulz, Peter Milovník, Clemens Mayer, Justin B. Siegel, David Baker, and Donald Hilvert

PNAS June 3, 2014 111 (22) 8013-8018; first published May 20, 2014. https://doi.org/10.1073/pnas.1401073111
Open Access
Binding of Pro-Gly-Pro at the active site of leukotriene A₄ hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
Alena Stsiapanava, Ulrika Olsson, Min Wan, Thea Kleinschmidt, Dorothea Rutishauser, Roman A. Zubarev, Bengt Samuelsson, Agnes Rinaldo-Matthis, and Jesper Z. Haeggström

PNAS March 18, 2014 111 (11) 4227-4232; https://doi.org/10.1073/pnas.1402136111

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