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genome engineering

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Codon usage of highly expressed genes affects proteome-wide translation efficiency
Idan Frumkin, Marc J. Lajoie, Christopher J. Gregg, Gil Hornung, George M. Church, and Yitzhak Pilpel

PNAS May 22, 2018 115 (21) E4940-E4949; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719375115
Open Access
Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture
Emily M. Darrow, Miriam H. Huntley, Olga Dudchenko, Elena K. Stamenova, Neva C. Durand, Zhuo Sun, Su-Chen Huang, Adrian L. Sanborn, Ido Machol, Muhammad Shamim, Andrew P. Seberg, Eric S. Lander, Brian P. Chadwick, and Erez Lieberman Aiden

PNAS August 2, 2016 113 (31) E4504-E4512; published ahead of print July 18, 2016. https://doi.org/10.1073/pnas.1609643113
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A scalable strategy for high-throughput GFP tagging of endogenous human proteins
Manuel D. Leonetti, Sayaka Sekine, Daichi Kamiyama, Jonathan S. Weissman, and Bo Huang

PNAS June 21, 2016 113 (25) E3501-E3508; published ahead of print June 6, 2016. https://doi.org/10.1073/pnas.1606731113
Open Access
A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species
Ákos Nyerges, Bálint Csörgő, István Nagy, Balázs Bálint, Péter Bihari, Viktória Lázár, Gábor Apjok, Kinga Umenhoffer, Balázs Bogos, György Pósfai, and Csaba Pál

PNAS March 1, 2016 113 (9) 2502-2507; published ahead of print February 16, 2016. https://doi.org/10.1073/pnas.1520040113
Open Access
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
Kathrin Schumann, Steven Lin, Eric Boyer, Dimitre R. Simeonov, Meena Subramaniam, Rachel E. Gate, Genevieve E. Haliburton, Chun J. Ye, Jeffrey A. Bluestone, Jennifer A. Doudna, and Alexander Marson

PNAS August 18, 2015 112 (33) 10437-10442; published ahead of print July 27, 2015. https://doi.org/10.1073/pnas.1512503112
Open Access
Rational design of a split-Cas9 enzyme complex
Addison V. Wright, Samuel H. Sternberg, David W. Taylor, Brett T. Staahl, Jorge A. Bardales, Jack E. Kornfeld, and Jennifer A. Doudna

PNAS March 10, 2015 112 (10) 2984-2989; published ahead of print February 23, 2015. https://doi.org/10.1073/pnas.1501698112
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Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
- From the Cover
Mark D. Szczelkun, Maria S. Tikhomirova, Tomas Sinkunas, Giedrius Gasiunas, Tautvydas Karvelis, Patrizia Pschera, Virginijus Siksnys, and Ralf Seidel

PNAS July 8, 2014 111 (27) 9798-9803; published ahead of print May 27, 2014. https://doi.org/10.1073/pnas.1402597111
Open Access
Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes
Lynn E. Macdonald, Margaret Karow, Sean Stevens, Wojtek Auerbach, William T. Poueymirou, Jason Yasenchak, David Frendewey, David M. Valenzuela, Cosmas C. Giallourakis, Frederick W. Alt, George D. Yancopoulos, and Andrew J. Murphy

PNAS April 8, 2014 111 (14) 5147-5152; published ahead of print March 25, 2014. https://doi.org/10.1073/pnas.1323896111
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Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis
- From the Cover
Zhengyan Feng, Yanfei Mao, Nanfei Xu, Botao Zhang, Pengliang Wei, Dong-Lei Yang, Zhen Wang, Zhengjing Zhang, Rui Zheng, Lan Yang, Liang Zeng, Xiaodong Liu, and Jian-Kang Zhu

PNAS March 25, 2014 111 (12) 4632-4637; https://doi.org/10.1073/pnas.1400822111
Open Access
Conditionals by inversion provide a universal method for the generation of conditional alleles
Aris N. Economides, David Frendewey, Peter Yang, Melissa G. Dominguez, Anthony T. Dore, Ivan B. Lobov, Trikaldarshi Persaud, Jose Rojas, Joyce McClain, Peter Lengyel, Gustavo Droguett, Rostislav Chernomorsky, Sean Stevens, Wojtek Auerbach, Thomas M. DeChiara, William Pouyemirou, Joseph M. Cruz Jr., Kieran Feeley, Ian A. Mellis, Jason Yasenchack, Sarah J. Hatsell, LiQin Xie, Esther Latres, Lily Huang, Yuhong Zhang, Evangelos Pefanis, Dimitris Skokos, Ron A. Deckelbaum, Susan D. Croll, Samuel Davis, David M. Valenzuela, Nicholas W. Gale, Andrew J. Murphy, and George D. Yancopoulos

PNAS August 20, 2013 110 (34) E3179-E3188; https://doi.org/10.1073/pnas.1217812110

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