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Hedgehog

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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit
Yunxiao Zhang, Wan-Jin Lu, David P. Bulkley, Jiahao Liang, Arthur Ralko, Shuo Han, Kelsey J. Roberts, Anping Li, Wonhwa Cho, Yifan Cheng, Aashish Manglik, and Philip A. Beachy

PNAS November 17, 2020 117 (46) 28838-28846; first published November 2, 2020. https://doi.org/10.1073/pnas.2011560117
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Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
Benjamin R. Myers, Lila Neahring, Yunxiao Zhang, Kelsey J. Roberts, and Philip A. Beachy

PNAS December 26, 2017 114 (52) E11141-E11150; first published December 11, 2017. https://doi.org/10.1073/pnas.1717891115
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EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling
Vincent J. Guen, Tony E. Chavarria, Cornelia Kröger, Xin Ye, Robert A. Weinberg, and Jacqueline A. Lees

PNAS December 5, 2017 114 (49) E10532-E10539; first published November 20, 2017. https://doi.org/10.1073/pnas.1711534114
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Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics
Bryn S. Moore, Ann N. Stepanchick, Paul H. Tewson, Cassandra M. Hartle, Jin Zhang, Anne Marie Quinn, Thomas E. Hughes, and Tooraj Mirshahi

PNAS November 15, 2016 113 (46) 13069-13074; first published October 31, 2016. https://doi.org/10.1073/pnas.1602393113
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Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog
Hanna Tukachinsky, Kostadin Petrov, Miyako Watanabe, and Adrian Salic

PNAS October 4, 2016 113 (40) E5866-E5875; first published September 19, 2016. https://doi.org/10.1073/pnas.1606719113
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Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium
Ying Xiao, Daniel T. Thoresen, Jonathan S. Williams, Chaochen Wang, James Perna, Ralitsa Petrova, and Isaac Brownell

PNAS June 9, 2015 112 (23) 7195-7200; first published May 26, 2015. https://doi.org/10.1073/pnas.1504177112
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Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction
Yuhong Han, Qing Shi, and Jin Jiang

PNAS May 19, 2015 112 (20) 6383-6388; first published May 4, 2015. https://doi.org/10.1073/pnas.1421628112
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Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation
Yu Shi, Jianquan Chen, Courtney M. Karner, and Fanxin Long

PNAS April 14, 2015 112 (15) 4678-4683; first published March 30, 2015. https://doi.org/10.1073/pnas.1502301112
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Endocannabinoids are conserved inhibitors of the Hedgehog pathway
Helena Khaliullina, Mesut Bilgin, Julio L. Sampaio, Andrej Shevchenko, and Suzanne Eaton

PNAS March 17, 2015 112 (11) 3415-3420; first published March 2, 2015. https://doi.org/10.1073/pnas.1416463112
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Mutant IDH is sufficient to initiate enchondromatosis in mice
Makoto Hirata, Masato Sasaki, Rob A. Cairns, Satoshi Inoue, Vijitha Puviindran, Wanda Y. Li, Bryan E. Snow, Lisa D. Jones, Qingxia Wei, Shingo Sato, Yuning J. Tang, Puviindran Nadesan, Jason Rockel, Heather Whetstone, Raymond Poon, Angela Weng, Stefan Gross, Kimberly Straley, Camelia Gliser, Yingxia Xu, Jay Wunder, Tak W. Mak, and Benjamin A. Alman

PNAS March 3, 2015 112 (9) 2829-2834; first published February 17, 2015. https://doi.org/10.1073/pnas.1424400112

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