New Research In

HLA

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Genome wide association study of HTLV-1–associated myelopathy/tropical spastic paraparesis in the Japanese population
Marina Penova, Shuji Kawaguchi, Jun-ichirou Yasunaga, Takahisa Kawaguchi, Tomoo Sato, Meiko Takahashi, Masakazu Shimizu, Mineki Saito, Kunihiro Tsukasaki, Masanori Nakagawa, Norihiro Takenouchi, Hideo Hara, Eiji Matsuura, Satoshi Nozuma, Hiroshi Takashima, Shuji Izumo, Toshiki Watanabe, Kaoru Uchimaru, Masako Iwanaga, Atae Utsunomiya, Yasuharu Tabara, Richard Paul, Yoshihisa Yamano, Masao Matsuoka, and Fumihiko Matsuda

PNAS March 16, 2021 118 (11) e2004199118; https://doi.org/10.1073/pnas.2004199118
Open Access
HLA tapasin independence: broader peptide repertoire and HIV control
Arman A. Bashirova, Mathias Viard, Vivek Naranbhai, Alba Grifoni, Wilfredo Garcia-Beltran, Marjan Akdag, Yuko Yuki, Xiaojiang Gao, Colm O’hUigin, Malini Raghavan, Steven Wolinsky, Jay H. Bream, Priya Duggal, Jeremy Martinson, Nelson L. Michael, Gregory D. Kirk, Susan P. Buchbinder, David Haas, James J. Goedert, Steven G. Deeks, Jacques Fellay, Bruce Walker, Philip Goulder, Peter Cresswell, Tim Elliott, Alessandro Sette, Jonathan Carlson, and Mary Carrington

PNAS November 10, 2020 117 (45) 28232-28238; first published October 23, 2020. https://doi.org/10.1073/pnas.2013554117
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HLA polymorphism and tapasin independence influence outcomes of HIV and dengue virus infection
- Nov 25, 2020
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The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function
Philippa M. Saunders, Bruce J. MacLachlan, Phillip Pymm, Patricia T. Illing, Yuanchen Deng, Shu Cheng Wong, Clare V. L. Oates, Anthony W. Purcell, Jamie Rossjohn, Julian P. Vivian, and Andrew G. Brooks

PNAS May 26, 2020 117 (21) 11636-11647; first published May 13, 2020. https://doi.org/10.1073/pnas.1920570117
Open Access
HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry
Pravitt Gourh, Sarah A. Safran, Theresa Alexander, Steven E. Boyden, Nadia D. Morgan, Ami A. Shah, Maureen D. Mayes, Ayo Doumatey, Amy R. Bentley, Daniel Shriner, Robyn T. Domsic, Thomas A. Medsger Jr, Paula S. Ramos, Richard M. Silver, Virginia D. Steen, John Varga, Vivien Hsu, Lesley Ann Saketkoo, Elena Schiopu, Dinesh Khanna, Jessica K. Gordon, Brynn Kron, Lindsey A. Criswell, Heather Gladue, Chris T. Derk, Elana J. Bernstein, S. Louis Bridges Jr, Victoria K. Shanmugam, Kathleen D. Kolstad, Lorinda Chung, Suzanne Kafaja, Reem Jan, Marcin Trojanowski, Avram Goldberg, Benjamin D. Korman, Peter J. Steinbach, Settara C. Chandrasekharappa, James C. Mullikin, Adebowale Adeyemo, Charles Rotimi, Fredrick M. Wigley, Daniel L. Kastner, Francesco Boin, and Elaine F. Remmers

PNAS January 7, 2020 117 (1) 552-562; first published December 23, 2019. https://doi.org/10.1073/pnas.1906593116
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Immunogenicity of a rheumatoid arthritis protective sequence when acquired through microchimerism
Sami B. Kanaan, Oyku Sensoy, Zhen Yan, Vijayakrishna K. Gadi, Michael L. Richardson, and J. Lee Nelson

PNAS September 24, 2019 116 (39) 19600-19608; first published September 9, 2019. https://doi.org/10.1073/pnas.1904779116
Open Access
A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson’s disease
Jill A. Hollenbach, Paul J. Norman, Lisa E. Creary, Vincent Damotte, Gonzalo Montero-Martin, Stacy Caillier, Kirsten M. Anderson, Maneesh K. Misra, Neda Nemat-Gorgani, Kazutoyo Osoegawa, Adam Santaniello, Adam Renschen, Wesley M. Marin, Ravi Dandekar, Peter Parham, Caroline M. Tanner, Stephen L. Hauser, Marcelo Fernandez-Viña, and Jorge R. Oksenberg

PNAS April 9, 2019 116 (15) 7419-7424; first published March 25, 2019. https://doi.org/10.1073/pnas.1821778116
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HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control
Jatin Arora, Paul J. McLaren, Nimisha Chaturvedi, Mary Carrington, Jacques Fellay, and Tobias L. Lenz

PNAS January 15, 2019 116 (3) 944-949; first published January 2, 2019. https://doi.org/10.1073/pnas.1812548116
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Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis
Chikashi Terao, Hajime Yoshifuji, Takayoshi Matsumura, Taeko K. Naruse, Tomonori Ishii, Yoshikazu Nakaoka, Yohei Kirino, Keitaro Matsuo, Tomoki Origuchi, Masakazu Shimizu, Yasuhiro Maejima, Eisuke Amiya, Natsuko Tamura, Takahisa Kawaguchi, Meiko Takahashi, Kazuya Setoh, Koichiro Ohmura, Ryu Watanabe, Tetsuya Horita, Tatsuya Atsumi, Mitsuru Matsukura, Tetsuro Miyata, Yuta Kochi, Toshio Suda, Kazuo Tanemoto, Akira Meguro, Yukinori Okada, Akiyoshi Ogimoto, Motohisa Yamamoto, Hiroki Takahashi, Shingo Nakayamada, Kazuyoshi Saito, Masataka Kuwana, Nobuhisa Mizuki, Yasuharu Tabara, Atsuhisa Ueda, Issei Komuro, Akinori Kimura, Mitsuaki Isobe, Tsuneyo Mimori, and Fumihiko Matsuda

PNAS December 18, 2018 115 (51) 13045-13050; first published November 29, 2018. https://doi.org/10.1073/pnas.1808850115
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Proinsulin C-peptide is an autoantigen in people with type 1 diabetes
Michelle So, Colleen M. Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja, John M. Wentworth, Leonard C. Harrison, Balasubramanian Krishnamurthy, Helen E. Thomas, Christine Rodda, Fergus J. Cameron, Jacinta McMahon, Thomas W. H. Kay, and Stuart I. Mannering

PNAS October 16, 2018 115 (42) 10732-10737; first published October 1, 2018. https://doi.org/10.1073/pnas.1809208115
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Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules
F. Tudor Ilca, Andreas Neerincx, Mark R. Wills, Maike de la Roche, and Louise H. Boyle

PNAS October 2, 2018 115 (40) E9353-E9361; first published September 13, 2018. https://doi.org/10.1073/pnas.1809465115

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