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HSP70

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The Hsp70 chaperone is a major player in stress-induced transposable element activation
- From the Cover
Ugo Cappucci, Fabrizia Noro, Assunta Maria Casale, Laura Fanti, Maria Berloco, Angela Alessandra Alagia, Luigi Grassi, Loredana Le Pera, Lucia Piacentini, and Sergio Pimpinelli

PNAS September 3, 2019 116 (36) 17943-17950; first published August 9, 2019. https://doi.org/10.1073/pnas.1903936116
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Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces
Wenli Meng, Eugenia M. Clerico, Natalie McArthur, and Lila M. Gierasch

PNAS November 20, 2018 115 (47) 11970-11975; first published November 5, 2018. https://doi.org/10.1073/pnas.1811105115
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Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb
Ashish Vora, Wenshuo Zhou, Berlin Londono-Renteria, Michael Woodson, Michael B. Sherman, Tonya M. Colpitts, Girish Neelakanta, and Hameeda Sultana

PNAS July 10, 2018 115 (28) E6604-E6613; first published June 26, 2018. https://doi.org/10.1073/pnas.1720125115
Open Access
Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides
Matthias C. Truttmann, David Pincus, and Hidde L. Ploegh

PNAS May 29, 2018 115 (22) E5008-E5017; first published May 14, 2018. https://doi.org/10.1073/pnas.1801989115
Open Access
Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response
Matthias C. Truttmann, Xu Zheng, Leo Hanke, Jadyn R. Damon, Monique Grootveld, Joanna Krakowiak, David Pincus, and Hidde L. Ploegh

PNAS January 10, 2017 114 (2) E152-E160; first published December 28, 2016. https://doi.org/10.1073/pnas.1619234114
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Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila
Pedro Fernandez-Funez, Jonatan Sanchez-Garcia, Lorena de Mena, Yan Zhang, Yona Levites, Swati Khare, Todd E. Golde, and Diego E. Rincon-Limas

PNAS August 30, 2016 113 (35) E5212-E5221; first published August 16, 2016. https://doi.org/10.1073/pnas.1608045113
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Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma
Amit J. Sabnis, Christopher J. Guerriero, Victor Olivas, Anin Sayana, Jonathan Shue, Jennifer Flanagan, Saurabh Asthana, Adrienne W. Paton, James C. Paton, Jason E. Gestwicki, Peter Walter, Jonathan S. Weissman, Peter Wipf, Jeffrey L. Brodsky, and Trever G. Bivona

PNAS August 9, 2016 113 (32) 9015-9020; first published July 22, 2016. https://doi.org/10.1073/pnas.1603883113
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Hsp70 biases the folding pathways of client proteins
Ashok Sekhar, Rina Rosenzweig, Guillaume Bouvignies, and Lewis E. Kay

PNAS May 17, 2016 113 (20) E2794-E2801; first published May 2, 2016. https://doi.org/10.1073/pnas.1601846113
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Exogenous Hsp70 delays senescence and improves cognitive function in aging mice
Natalia V. Bobkova, Mikhail Evgen’ev, David G. Garbuz, Alexei M. Kulikov, Alexei Morozov, Alexander Samokhin, Dmitri Velmeshev, Natalia Medvinskaya, Inna Nesterova, Andrew Pollock, and Evgeny Nudler

PNAS December 29, 2015 112 (52) 16006-16011; first published December 14, 2015. https://doi.org/10.1073/pnas.1516131112
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Mapping the conformation of a client protein through the Hsp70 functional cycle
Ashok Sekhar, Rina Rosenzweig, Guillaume Bouvignies, and Lewis E. Kay

PNAS August 18, 2015 112 (33) 10395-10400; first published August 3, 2015. https://doi.org/10.1073/pnas.1508504112

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