New Research In

macrophage

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Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4
Pedro M. Moraes-Vieira, Mark M. Yore, Alexandra Sontheimer-Phelps, Angela Castoldi, Julie Norseen, Pratik Aryal, Kotryna Simonyté Sjödin, and Barbara B. Kahn

PNAS December 8, 2020 117 (49) 31309-31318; first published November 19, 2020. https://doi.org/10.1073/pnas.2013877117
Open Access
Label-free adaptive optics imaging of human retinal macrophage distribution and dynamics
Daniel X. Hammer, Anant Agrawal, Ricardo Villanueva, Osamah Saeedi, and Zhuolin Liu

PNAS December 1, 2020 117 (48) 30661-30669; first published November 9, 2020. https://doi.org/10.1073/pnas.2010943117
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A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation
Yukiteru Nakayama, Katsuhito Fujiu, Ryuzaburo Yuki, Yumiko Oishi, Masaki Suimye Morioka, Takayuki Isagawa, Jun Matsuda, Tsukasa Oshima, Takumi Matsubara, Junichi Sugita, Fujimi Kudo, Atsushi Kaneda, Yusuke Endo, Toshinori Nakayama, Ryozo Nagai, Issei Komuro, and Ichiro Manabe

PNAS June 23, 2020 117 (25) 14365-14375; first published June 8, 2020. https://doi.org/10.1073/pnas.2005924117
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Noncoding RNA MaIL1 is an integral component of the TLR4–TRIF pathway
Marina Aznaourova, Harshavardhan Janga, Stephanie Sefried, Andreas Kaufmann, Jens Dorna, Sarah M. Volkers, Philipp Georg, Marcus Lechner, Judith Hoppe, Simon Dökel, Nils Schmerer, Achim D. Gruber, Uwe Linne, Stefan Bauer, Leif E. Sander, Bernd Schmeck, and Leon N. Schulte

PNAS April 21, 2020 117 (16) 9042-9053; first published April 2, 2020. https://doi.org/10.1073/pnas.1920393117
Open Access
Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells
Devaraj Basavarajappa, Stella Uebbing, Marius Kreiss, Ana Lukic, Beatrix Suess, Dieter Steinhilber, Bengt Samuelsson, and Olof Rådmark

PNAS April 14, 2020 117 (15) 8573-8583; first published March 27, 2020. https://doi.org/10.1073/pnas.1916249117
Open Access
The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination
- From the Cover
Christopher E. McMurran, Alerie Guzman de la Fuente, Rosana Penalva, Ofra Ben Menachem-Zidon, Yvonne Dombrowski, John Falconer, Ginez A. Gonzalez, Chao Zhao, Fynn N. Krause, Adam M. H. Young, Julian L. Griffin, Clare A. Jones, Claire Hollins, Markus M. Heimesaat, Denise C. Fitzgerald, and Robin J. M. Franklin

PNAS December 10, 2019 116 (50) 25311-25321; first published November 18, 2019. https://doi.org/10.1073/pnas.1905787116
See companion article:
Remyelination and the gut−brain axis
- Nov 25, 2019
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Myeloid cells activate iNKT cells to produce IL-4 in the thymic medulla
Haiguang Wang, Elise R. Breed, You Jeong Lee, Lily J. Qian, Stephen C. Jameson, and Kristin A. Hogquist

PNAS October 29, 2019 116 (44) 22262-22268; first published October 14, 2019. https://doi.org/10.1073/pnas.1910412116
Open Access
Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis
Fangfang Chen, Peer Lukat, Azeem Ahmed Iqbal, Kyrill Saile, Volkhard Kaever, Joop van den Heuvel, Wulf Blankenfeldt, Konrad Büssow, and Frank Pessler

PNAS October 8, 2019 116 (41) 20644-20654; first published September 23, 2019. https://doi.org/10.1073/pnas.1908770116
Open Access
STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation
Saroj Nepal, Chinnaswamy Tiruppathi, Yoshikazu Tsukasaki, Joseph Farahany, Manish Mittal, Jalees Rehman, Darwin J. Prockop, and Asrar B. Malik

PNAS August 13, 2019 116 (33) 16513-16518; first published July 30, 2019. https://doi.org/10.1073/pnas.1821601116
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Intravital 2-photon imaging reveals distinct morphology and infiltrative properties of glioblastoma-associated macrophages
Zhihong Chen, James L. Ross, and Dolores Hambardzumyan

PNAS July 9, 2019 116 (28) 14254-14259; first published June 24, 2019. https://doi.org/10.1073/pnas.1902366116

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