New Research In

mechanosensing

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Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose
Dilip Thomas, Grazia Marsico, Isma Liza Mohd Isa, Arun Thirumaran, Xizhe Chen, Bartlomiej Lukasz, Gianluca Fontana, Brian Rodriguez, Martina Marchetti-Deschmann, Timothy O’Brien, and Abhay Pandit

PNAS August 11, 2020 117 (32) 19033-19044; first published July 24, 2020. https://doi.org/10.1073/pnas.2008245117
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The E. coli transcription factor GrlA is regulated by subcellular compartmentalization and activated in response to mechanical stimuli
Natalie Sirisaengtaksin, Max A. Odem, Rachel E. Bosserman, Erika M. Flores, and Anne Marie Krachler

PNAS April 28, 2020 117 (17) 9519-9528; first published April 10, 2020. https://doi.org/10.1073/pnas.1917500117
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Biphasic mechanosensitivity of T cell receptor-mediated spreading of lymphocytes
Astrid Wahl, Céline Dinet, Pierre Dillard, Aya Nassereddine, Pierre-Henri Puech, Laurent Limozin, and Kheya Sengupta

PNAS March 26, 2019 116 (13) 5908-5913; first published March 8, 2019. https://doi.org/10.1073/pnas.1811516116
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Lamellipodium is a myosin-independent mechanosensor
Patrick W. Oakes, Tamara C. Bidone, Yvonne Beckham, Austin V. Skeeters, Guillermina R. Ramirez-San Juan, Stephen P. Winter, Gregory A. Voth, and Margaret L. Gardel

PNAS March 13, 2018 115 (11) 2646-2651; first published February 27, 2018. https://doi.org/10.1073/pnas.1715869115
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Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration
Min-Cheol Kim, Yaron R. Silberberg, Rohan Abeyaratne, Roger D. Kamm, and H. Harry Asada

PNAS January 16, 2018 115 (3) E390-E399; first published January 2, 2018. https://doi.org/10.1073/pnas.1717230115
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SCWISh network is essential for survival under mechanical pressure
Morgan Delarue, Gregory Poterewicz, Ori Hoxha, Jessica Choi, Wonjung Yoo, Jona Kayser, Liam Holt, and Oskar Hallatschek

PNAS December 19, 2017 114 (51) 13465-13470; first published November 29, 2017. https://doi.org/10.1073/pnas.1711204114
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Mechanotransduction in yeast
- Dec 01, 2017
Open Access
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
Vinay Swaminathan, Joseph Mathew Kalappurakkal, Shalin B. Mehta, Pontus Nordenfelt, Travis I. Moore, Nobuyasu Koga, David A. Baker, Rudolf Oldenbourg, Tomomi Tani, Satyajit Mayor, Timothy A. Springer, and Clare M. Waterman

PNAS October 3, 2017 114 (40) 10648-10653; https://doi.org/10.1073/pnas.1701136114
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Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices
- From the Cover
Xuan Cao, Ehsan Ban, Brendon M. Baker, Yuan Lin, Jason A. Burdick, Christopher S. Chen, and Vivek B. Shenoy

PNAS June 6, 2017 114 (23) E4549-E4555; first published May 3, 2017. https://doi.org/10.1073/pnas.1620486114
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Fibrous nature of cellular microenvironments
- May 26, 2017
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Mechanosensing of shear by Pseudomonas aeruginosa leads to increased levels of the cyclic-di-GMP signal initiating biofilm development
Christopher A. Rodesney, Brian Roman, Numa Dhamani, Benjamin J. Cooley, Parag Katira, Ahmed Touhami, and Vernita D. Gordon

PNAS June 6, 2017 114 (23) 5906-5911; first published May 22, 2017. https://doi.org/10.1073/pnas.1703255114
Open Access
Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling
Andrew Dittmore, Jonathan Silver, Susanta K. Sarkar, Barry Marmer, Gregory I. Goldberg, and Keir C. Neuman

PNAS July 26, 2016 113 (30) 8436-8441; first published July 11, 2016. https://doi.org/10.1073/pnas.1523228113

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