oncogene addiction

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Addiction to multiple oncogenes can be exploited to prevent the emergence of therapeutic resistance
Peter S. Choi, Yulin Li, and Dean W. Felsher

PNAS August 12, 2014 111 (32) E3316-E3324; first published July 28, 2014. https://doi.org/10.1073/pnas.1406123111
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Selective requirement for Mediator MED23 in Ras-active lung cancer
Xu Yang, Meng Zhao, Min Xia, Yuting Liu, Jun Yan, Hongbin Ji, and Gang Wang

PNAS October 9, 2012 109 (41) E2813-E2822; https://doi.org/10.1073/pnas.1204311109
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Complex oncogene dependence in microRNA-125a–induced myeloproliferative neoplasms
Shangqin Guo, Haitao Bai, Cynthia M. Megyola, Stephanie Halene, Diane S. Krause, David T. Scadden, and Jun Lu

PNAS October 9, 2012 109 (41) 16636-16641; https://doi.org/10.1073/pnas.1213196109
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Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
Gromoslaw A. Smolen, Raffaella Sordella, Beth Muir, Gayatry Mohapatra, Anne Barmettler, Heidi Archibald, Woo J. Kim, Ross A. Okimoto, Daphne W. Bell, Dennis C. Sgroi, James G. Christensen, Jeffrey Settleman, and Daniel A. Haber

PNAS February 14, 2006 103 (7) 2316-2321; first published February 6, 2006. https://doi.org/10.1073/pnas.0508776103

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