New Research In

Parkinson's disease

Open Access
α-synuclein−lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients
Wojciech Paslawski, Justyna Zareba-Paslawska, Xiaoqun Zhang, Katharina Hölzl, Henrik Wadensten, Mohammadreza Shariatgorji, Shorena Janelidze, Oskar Hansson, Lars Forsgren, Per E. Andrén, and Per Svenningsson

PNAS July 23, 2019 116 (30) 15226-15235; first published July 3, 2019. https://doi.org/10.1073/pnas.1821409116
Open Access
Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death
Elisa Turriani, Diana F. Lázaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schön, Michael P. Schön, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, and Dorothea Becker

PNAS June 20, 2017 114 (25) E4971-E4977; first published June 5, 2017. https://doi.org/10.1073/pnas.1700200114
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Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease
- From the Cover
Athanasios D. Spathis, Xenophon Asvos, Despina Ziavra, Theodoros Karampelas, Stavros Topouzis, Zoe Cournia, Xiaobing Qing, Pavlos Alexakos, Lisa M. Smits, Christina Dalla, Hardy J. Rideout, Jens Christian Schwamborn, Constantin Tamvakopoulos, Demosthenes Fokas, and Demetrios K. Vassilatis

PNAS April 11, 2017 114 (15) 3999-4004; first published March 27, 2017. https://doi.org/10.1073/pnas.1616874114
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Toward neuroprotective treatments of PD
- Mar 30, 2017
Open Access
Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease
- From the Cover
Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, and Per Svenningsson

PNAS March 7, 2017 114 (10) 2735-2740; first published January 30, 2017. https://doi.org/10.1073/pnas.1621218114
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Depression and inflammation in PD as biomarker
- Mar 10, 2017
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Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
- From the Cover
Wei Wang, Linh T. T. Nguyen, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S. Fisher, David W. Miller, Debajyoti Datta, Fang Wu, Chun-Xiang Wu, Anuradha Landeru, James A. Wells, Mark R. Cookson, Matthew B. Boxer, Craig J. Thomas, Wei Ping Gai, Dagmar Ringe, Gregory A. Petsko, and Quyen Q. Hoang

PNAS August 23, 2016 113 (34) 9587-9592; first published August 1, 2016. https://doi.org/10.1073/pnas.1610099113
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VX-765 rescues α-synuclein–induced neuropathology
- Aug 01, 2016
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αSyn truncation by caspase-1 in synucleinopathies
- Aug 22, 2016
Open Access
Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice
Maxwell A. Sherman, Shane Lee, Robert Law, Saskia Haegens, Catherine A. Thorn, Matti S. Hämäläinen, Christopher I. Moore, and Stephanie R. Jones

PNAS August 16, 2016 113 (33) E4885-E4894; first published July 28, 2016. https://doi.org/10.1073/pnas.1604135113
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Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons
Hélène Doucet-Beaupré, Catherine Gilbert, Marcos Schaan Profes, Audrey Chabrat, Consiglia Pacelli, Nicolas Giguère, Véronique Rioux, Julien Charest, Qiaolin Deng, Ariadna Laguna, Johan Ericson, Thomas Perlmann, Siew-Lan Ang, Francesca Cicchetti, Martin Parent, Louis-Eric Trudeau, and Martin Lévesque

PNAS July 26, 2016 113 (30) E4387-E4396; first published July 12, 2016. https://doi.org/10.1073/pnas.1520387113
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Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism
Paul D. Dodson, Jakob K. Dreyer, Katie A. Jennings, Emilie C. J. Syed, Richard Wade-Martins, Stephanie J. Cragg, J. Paul Bolam, and Peter J. Magill

PNAS April 12, 2016 113 (15) E2180-E2188; first published March 21, 2016. https://doi.org/10.1073/pnas.1515941113
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Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2
Friederike Zunke, Lisa Andresen, Sophia Wesseler, Johann Groth, Philipp Arnold, Michelle Rothaug, Joseph R. Mazzulli, Dimitri Krainc, Judith Blanz, Paul Saftig, and Michael Schwake

PNAS April 5, 2016 113 (14) 3791-3796; first published March 21, 2016. https://doi.org/10.1073/pnas.1514005113
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α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
Joseph R. Mazzulli, Friederike Zunke, Ole Isacson, Lorenz Studer, and Dimitri Krainc

PNAS February 16, 2016 113 (7) 1931-1936; first published February 2, 2016. https://doi.org/10.1073/pnas.1520335113

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