New Research In

Parkinson's disease

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Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death
Elisa Turriani, Diana F. Lázaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schön, Michael P. Schön, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, and Dorothea Becker

PNAS June 20, 2017 114 (25) E4971-E4977; published ahead of print June 5, 2017. https://doi.org/10.1073/pnas.1700200114
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Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease
- From the Cover
Athanasios D. Spathis, Xenophon Asvos, Despina Ziavra, Theodoros Karampelas, Stavros Topouzis, Zoe Cournia, Xiaobing Qing, Pavlos Alexakos, Lisa M. Smits, Christina Dalla, Hardy J. Rideout, Jens Christian Schwamborn, Constantin Tamvakopoulos, Demosthenes Fokas, and Demetrios K. Vassilatis

PNAS April 11, 2017 114 (15) 3999-4004; published ahead of print March 27, 2017. https://doi.org/10.1073/pnas.1616874114
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Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease
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Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, and Per Svenningsson

PNAS March 7, 2017 114 (10) 2735-2740; published ahead of print January 30, 2017. https://doi.org/10.1073/pnas.1621218114
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Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
- From the Cover
Wei Wang, Linh T. T. Nguyen, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S. Fisher, David W. Miller, Debajyoti Datta, Fang Wu, Chun-Xiang Wu, Anuradha Landeru, James A. Wells, Mark R. Cookson, Matthew B. Boxer, Craig J. Thomas, Wei Ping Gai, Dagmar Ringe, Gregory A. Petsko, and Quyen Q. Hoang

PNAS August 23, 2016 113 (34) 9587-9592; published ahead of print August 1, 2016. https://doi.org/10.1073/pnas.1610099113
Open Access
Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice
Maxwell A. Sherman, Shane Lee, Robert Law, Saskia Haegens, Catherine A. Thorn, Matti S. Hämäläinen, Christopher I. Moore, and Stephanie R. Jones

PNAS August 16, 2016 113 (33) E4885-E4894; published ahead of print July 28, 2016. https://doi.org/10.1073/pnas.1604135113
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Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons
Hélène Doucet-Beaupré, Catherine Gilbert, Marcos Schaan Profes, Audrey Chabrat, Consiglia Pacelli, Nicolas Giguère, Véronique Rioux, Julien Charest, Qiaolin Deng, Ariadna Laguna, Johan Ericson, Thomas Perlmann, Siew-Lan Ang, Francesca Cicchetti, Martin Parent, Louis-Eric Trudeau, and Martin Lévesque

PNAS July 26, 2016 113 (30) E4387-E4396; published ahead of print July 12, 2016. https://doi.org/10.1073/pnas.1520387113
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Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism
Paul D. Dodson, Jakob K. Dreyer, Katie A. Jennings, Emilie C. J. Syed, Richard Wade-Martins, Stephanie J. Cragg, J. Paul Bolam, and Peter J. Magill

PNAS April 12, 2016 113 (15) E2180-E2188; published ahead of print March 21, 2016. https://doi.org/10.1073/pnas.1515941113
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Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2
Friederike Zunke, Lisa Andresen, Sophia Wesseler, Johann Groth, Philipp Arnold, Michelle Rothaug, Joseph R. Mazzulli, Dimitri Krainc, Judith Blanz, Paul Saftig, and Michael Schwake

PNAS April 5, 2016 113 (14) 3791-3796; published ahead of print March 21, 2016. https://doi.org/10.1073/pnas.1514005113
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α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
Joseph R. Mazzulli, Friederike Zunke, Ole Isacson, Lorenz Studer, and Dimitri Krainc

PNAS February 16, 2016 113 (7) 1931-1936; published ahead of print February 2, 2016. https://doi.org/10.1073/pnas.1520335113
Open Access
Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice
Roberta Marongiu, Margarita Arango-Lievano, Veronica Francardo, Peter Morgenstern, Xiaoqun Zhang, M. Angela Cenci, Per Svenningsson, Paul Greengard, and Michael G. Kaplitt

PNAS February 2, 2016 113 (5) 1423-1428; published ahead of print January 19, 2016. https://doi.org/10.1073/pnas.1524387113

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