Patched

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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit
Yunxiao Zhang, Wan-Jin Lu, David P. Bulkley, Jiahao Liang, Arthur Ralko, Shuo Han, Kelsey J. Roberts, Anping Li, Wonhwa Cho, Yifan Cheng, Aashish Manglik, and Philip A. Beachy

PNAS November 17, 2020 117 (46) 28838-28846; first published November 2, 2020. https://doi.org/10.1073/pnas.2011560117
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Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol
Lucien E. Weiss, Ljiljana Milenkovic, Joshua Yoon, Tim Stearns, and W. E. Moerner

PNAS March 19, 2019 116 (12) 5550-5557; first published February 28, 2019. https://doi.org/10.1073/pnas.1816747116
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Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
Benjamin R. Myers, Lila Neahring, Yunxiao Zhang, Kelsey J. Roberts, and Philip A. Beachy

PNAS December 26, 2017 114 (52) E11141-E11150; first published December 11, 2017. https://doi.org/10.1073/pnas.1717891115
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Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog
Hanna Tukachinsky, Kostadin Petrov, Miyako Watanabe, and Adrian Salic

PNAS October 4, 2016 113 (40) E5866-E5875; first published September 19, 2016. https://doi.org/10.1073/pnas.1606719113

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