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retinal degeneration

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Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina
Shoji Notomi, Kenji Ishihara, Nikolaos E. Efstathiou, Jong-Jer Lee, Toshio Hisatomi, Takashi Tachibana, Eleni K. Konstantinou, Takashi Ueta, Yusuke Murakami, Daniel E. Maidana, Yasuhiro Ikeda, Shinji Kume, Hiroto Terasaki, Shozo Sonoda, Judith Blanz, Lucy Young, Taiji Sakamoto, Koh-Hei Sonoda, Paul Saftig, Tatsuro Ishibashi, Joan W. Miller, Guido Kroemer, and Demetrios G. Vavvas

PNAS November 19, 2019 116 (47) 23724-23734; first published November 7, 2019. https://doi.org/10.1073/pnas.1906643116
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Retinal and optic nerve degeneration in liver X receptor β knockout mice
Xiao-yu Song, Wan-fu Wu, Chiara Gabbi, Yu-bing Dai, Mark So, Surendra P. Chaurasiya, Li Wang, Margaret Warner, and Jan-Åke Gustafsson

PNAS August 13, 2019 116 (33) 16507-16512; first published August 1, 2019. https://doi.org/10.1073/pnas.1904719116
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PRCD is essential for high-fidelity photoreceptor disc formation
- From the Cover
William J. Spencer, Jin-Dong Ding, Tylor R. Lewis, Chen Yu, Sebastien Phan, Jillian N. Pearring, Keun-Young Kim, Andrea Thor, Rose Mathew, Joan Kalnitsky, Ying Hao, Amanda M. Travis, Sondip K. Biswas, Woo-Kuen Lo, Joseph C. Besharse, Mark H. Ellisman, Daniel R. Saban, Marie E. Burns, and Vadim Y. Arshavsky

PNAS June 25, 2019 116 (26) 13087-13096; first published June 12, 2019. https://doi.org/10.1073/pnas.1906421116
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Loss of MPC1 reprograms retinal metabolism to impair visual function
Allison Grenell, Yekai Wang, Michelle Yam, Aditi Swarup, Tanya L. Dilan, Allison Hauer, Jonathan D. Linton, Nancy J. Philp, Elizabeth Gregor, Siyan Zhu, Quan Shi, Joseph Murphy, Tongju Guan, Daniel Lohner, Saravanan Kolandaivelu, Visvanathan Ramamurthy, Andrew F. X. Goldberg, James B. Hurley, and Jianhai Du

PNAS February 26, 2019 116 (9) 3530-3535; first published February 11, 2019. https://doi.org/10.1073/pnas.1812941116
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Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP
Qihong Zhang, Joseph C. Giacalone, Charles Searby, Edwin M. Stone, Budd A. Tucker, and Val C. Sheffield

PNAS January 22, 2019 116 (4) 1353-1360; first published January 8, 2019. https://doi.org/10.1073/pnas.1817639116
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VEGF-B is a potent antioxidant
Pachiappan Arjunan, Xianchai Lin, Zhongshu Tang, Yuxiang Du, Anil Kumar, Lixian Liu, Xiangke Yin, Lijuan Huang, Wei Chen, Qishan Chen, Zhimin Ye, Shasha Wang, Haiqing Kuang, Linbin Zhou, Kai Xu, Xue Chen, Haitao Zeng, Weisi Lu, Yihai Cao, Yizhi Liu, Chen Zhao, and Xuri Li

PNAS October 9, 2018 115 (41) 10351-10356; first published September 24, 2018. https://doi.org/10.1073/pnas.1801379115
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Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector
Artur V. Cideciyan, Raghavi Sudharsan, Valérie L. Dufour, Michael T. Massengill, Simone Iwabe, Malgorzata Swider, Brianna Lisi, Alexander Sumaroka, Luis Felipe Marinho, Tatyana Appelbaum, Brian Rossmiller, William W. Hauswirth, Samuel G. Jacobson, Alfred S. Lewin, Gustavo D. Aguirre, and William A. Beltran

PNAS September 4, 2018 115 (36) E8547-E8556; first published August 20, 2018. https://doi.org/10.1073/pnas.1805055115
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Antagonistic regulation of trafficking to Caenorhabditis elegans sensory cilia by a Retinal Degeneration 3 homolog and retromer
Luis A. Martínez-Velázquez and Niels Ringstad

PNAS January 16, 2018 115 (3) E438-E447; first published December 27, 2017. https://doi.org/10.1073/pnas.1712302115
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Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration
Hiroshi Shirai, Michiko Mandai, Keizo Matsushita, Atsushi Kuwahara, Shigenobu Yonemura, Tokushige Nakano, Juthaporn Assawachananont, Toru Kimura, Koichi Saito, Hiroko Terasaki, Mototsugu Eiraku, Yoshiki Sasai, and Masayo Takahashi

PNAS January 5, 2016 113 (1) E81-E90; first published December 22, 2015. https://doi.org/10.1073/pnas.1512590113
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Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease
William A. Beltran, Artur V. Cideciyan, Simone Iwabe, Malgorzata Swider, Mychajlo S. Kosyk, Kendra McDaid, Inna Martynyuk, Gui-Shuang Ying, James Shaffer, Wen-Tao Deng, Sanford L. Boye, Alfred S. Lewin, William W. Hauswirth, Samuel G. Jacobson, and Gustavo D. Aguirre

PNAS October 27, 2015 112 (43) E5844-E5853; first published October 12, 2015. https://doi.org/10.1073/pnas.1509914112

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