New Research In

single-molecule force spectroscopy

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Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin
Rachel Leicher, Eva J. Ge, Xingcheng Lin, Matthew J. Reynolds, Wenjun Xie, Thomas Walz, Bin Zhang, Tom W. Muir, and Shixin Liu

PNAS December 1, 2020 117 (48) 30465-30475; first published November 18, 2020. https://doi.org/10.1073/pnas.2003395117
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Nanomechanical properties of steric zipper globular structures
Neta Lester-Zer, Mnar Ghrayeb, and Liraz Chai

PNAS November 5, 2019 116 (45) 22478-22484; first published October 21, 2019. https://doi.org/10.1073/pnas.1908782116
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Structural and mechanistic insights into mechanoactivation of focal adhesion kinase
Magnus Sebastian Bauer, Fabian Baumann, Csaba Daday, Pilar Redondo, Ellis Durner, Markus Andreas Jobst, Lukas Frederik Milles, Davide Mercadante, Diana Angela Pippig, Hermann Eduard Gaub, Frauke Gräter, and Daniel Lietha

PNAS April 2, 2019 116 (14) 6766-6774; first published March 15, 2019. https://doi.org/10.1073/pnas.1820567116
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A small single-domain protein folds through the same pathway on and off the ribosome
Emily J. Guinn, Pengfei Tian, Mia Shin, Robert B. Best, and Susan Marqusee

PNAS November 27, 2018 115 (48) 12206-12211; first published November 8, 2018. https://doi.org/10.1073/pnas.1810517115
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Folding pathway of an Ig domain is conserved on and off the ribosome
- Nov 09, 2018
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Dynamic force spectroscopy of synthetic oligorotaxane foldamers
- From the Cover
Damien Sluysmans, Floriane Devaux, Carson J. Bruns, J. Fraser Stoddart, and Anne-Sophie Duwez

PNAS September 18, 2018 115 (38) 9362-9366; first published December 26, 2017. https://doi.org/10.1073/pnas.1712790115
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Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins
Jaime Andrés Rivas-Pardo, Carmen L. Badilla, Rafael Tapia-Rojo, Álvaro Alonso-Caballero, and Julio M. Fernández

PNAS September 11, 2018 115 (37) 9222-9227; first published August 27, 2018. https://doi.org/10.1073/pnas.1807689115
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CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks
Daniel J. Echelman, Jorge Alegre-Cebollada, Carmen L. Badilla, Chungyu Chang, Hung Ton-That, and Julio M. Fernández

PNAS March 1, 2016 113 (9) 2490-2495; first published February 16, 2016. https://doi.org/10.1073/pnas.1522946113
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Force-dependent switch in protein unfolding pathways and transition-state movements
Pavel I. Zhuravlev, Michael Hinczewski, Shaon Chakrabarti, Susan Marqusee, and D. Thirumalai

PNAS February 9, 2016 113 (6) E715-E724; first published January 27, 2016. https://doi.org/10.1073/pnas.1515730113
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Relevance of in vitro biophysical studies
- May 25, 2016
Open Access
Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction
Jochen P. Müller, Salomé Mielke, Achim Löf, Tobias Obser, Christof Beer, Linda K. Bruetzel, Diana A. Pippig, Willem Vanderlinden, Jan Lipfert, Reinhard Schneppenheim, and Martin Benoit

PNAS February 2, 2016 113 (5) 1208-1213; first published January 19, 2016. https://doi.org/10.1073/pnas.1516214113
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How osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory
Jagannath Mondal, Duncan Halverson, Isaac T. S. Li, Guillaume Stirnemann, Gilbert C. Walker, and Bruce J. Berne

PNAS July 28, 2015 112 (30) 9270-9275; first published July 13, 2015. https://doi.org/10.1073/pnas.1511780112

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