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stroke

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Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior
Sara Palma-Tortosa, Daniel Tornero, Marita Grønning Hansen, Emanuela Monni, Mazin Hajy, Sopiko Kartsivadze, Sibel Aktay, Oleg Tsupykov, Malin Parmar, Karl Deisseroth, Galyna Skibo, Olle Lindvall, and Zaal Kokaia

PNAS April 21, 2020 117 (16) 9094-9100; first published April 6, 2020. https://doi.org/10.1073/pnas.2000690117
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Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage
Daniela Mauceri, Bettina Buchthal, Thekla J. Hemstedt, Ursula Weiss, Christian D. Klein, and Hilmar Bading

PNAS April 14, 2020 117 (15) 8616-8623; first published March 30, 2020. https://doi.org/10.1073/pnas.2001563117
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Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke
Masanori Gomi Naito, Daichao Xu, Palak Amin, Jinwoo Lee, Huibing Wang, Wanjin Li, Michelle Kelliher, Manolis Pasparakis, and Junying Yuan

PNAS March 3, 2020 117 (9) 4959-4970; first published February 18, 2020. https://doi.org/10.1073/pnas.1916427117
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Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes
Abdullah Al Mamun, Anjali Chauhan, Shaohua Qi, Conelius Ngwa, Yan Xu, Romana Sharmeen, Amy L. Hazen, Jun Li, Jaroslaw A. Aronowski, Louise D. McCullough, and Fudong Liu

PNAS January 21, 2020 117 (3) 1742-1752; first published December 31, 2019. https://doi.org/10.1073/pnas.1914742117
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A small molecule protects mitochondrial integrity by inhibiting mTOR activity
Ran Cao, Li Li, Zhengxin Ying, Zichen Cao, Yongfen Ma, Xiaoxu Mao, Jiaojiao Li, Xiangbing Qi, Zhiyuan Zhang, and Xiaodong Wang

PNAS November 12, 2019 116 (46) 23332-23338; first published October 25, 2019. https://doi.org/10.1073/pnas.1911246116
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PGE₂ signaling via the neuronal EP2 receptor increases injury in a model of cerebral ischemia
Qingkun Liu, Xibin Liang, Qian Wang, Edward N. Wilson, Rachel Lam, Jing Wang, William Kong, Connie Tsai, Tingting Pan, Paul B. Larkin, Mehrdad Shamloo, and Katrin I. Andreasson

PNAS May 14, 2019 116 (20) 10019-10024; first published April 29, 2019. https://doi.org/10.1073/pnas.1818544116
Open Access
From single drug targets to synergistic network pharmacology in ischemic stroke
Ana I. Casas, Ahmed A. Hassan, Simon J. Larsen, Vanessa Gomez-Rangel, Mahmoud Elbatreek, Pamela W. M. Kleikers, Emre Guney, Javier Egea, Manuela G. López, Jan Baumbach, and Harald H. H. W. Schmidt

PNAS April 2, 2019 116 (14) 7129-7136; first published March 20, 2019. https://doi.org/10.1073/pnas.1820799116
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Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death
Min Qiang, Xue Dong, Zhao Zha, Xiao-Kun Zuo, Xing-Lei Song, Lixia Zhao, Chao Yuan, Chen Huang, Pingdong Tao, Qin Hu, Wei-Guang Li, Wanhui Hu, Jie Li, Yan Nie, Damiano Buratto, Francesco Zonta, Peixiang Ma, Zheng Yu, Lili Liu, Yi Zhang, Bei Yang, Jia Xie, Tian-Le Xu, Zhihu Qu, Guang Yang, and Richard A. Lerner

PNAS August 7, 2018 115 (32) E7469-E7477; first published July 24, 2018. https://doi.org/10.1073/pnas.1807233115
Open Access
Motor dexterity and strength depend upon integrity of the attention-control system
Paul Rinne, Mursyida Hassan, Cristina Fernandes, Erika Han, Emma Hennessy, Adam Waldman, Pankaj Sharma, David Soto, Robert Leech, Paresh A. Malhotra, and Paul Bentley

PNAS January 16, 2018 115 (3) E536-E545; first published December 28, 2017. https://doi.org/10.1073/pnas.1715617115
Open Access
NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage
Ana I. Casas, Eva Geuss, Pamela W. M. Kleikers, Stine Mencl, Alexander M. Herrmann, Izaskun Buendia, Javier Egea, Sven G. Meuth, Manuela G. Lopez, Christoph Kleinschnitz, and Harald H. H. W. Schmidt

PNAS November 14, 2017 114 (46) 12315-12320; first published October 31, 2017. https://doi.org/10.1073/pnas.1705034114

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