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structural biology

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Structural basis of nanobody recognition of grapevine fanleaf virus and of virus resistance loss
Igor Orlov, Caroline Hemmer, Léa Ackerer, Bernard Lorber, Ahmed Ghannam, Vianney Poignavent, Kamal Hleibieh, Claude Sauter, Corinne Schmitt-Keichinger, Lorène Belval, Jean-Michel Hily, Aurélie Marmonier, Véronique Komar, Sophie Gersch, Pascale Schellenberger, Patrick Bron, Emmanuelle Vigne, Serge Muyldermans, Olivier Lemaire, Gérard Demangeat, Christophe Ritzenthaler, and Bruno P. Klaholz

PNAS May 19, 2020 117 (20) 10848-10855; first published May 5, 2020. https://doi.org/10.1073/pnas.1913681117
Open Access
Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain
Thuy N. Vien, Jinliang Wang, Leo C. T. Ng, Erhu Cao, and Paul G. DeCaen

PNAS May 12, 2020 117 (19) 10329-10338; first published April 24, 2020. https://doi.org/10.1073/pnas.1920777117
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An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2
Hyun-Seo Kang, Carolina Sánchez-Rico, Stefanie Ebersberger, F. X. Reymond Sutandy, Anke Busch, Thomas Welte, Ralf Stehle, Clara Hipp, Laura Schulz, Andreas Buchbender, Kathi Zarnack, Julian König, and Michael Sattler

PNAS March 31, 2020 117 (13) 7140-7149; first published March 18, 2020. https://doi.org/10.1073/pnas.1913483117
Open Access
On the evolution of protein–adenine binding
Aya Narunsky, Amit Kessel, Ron Solan, Vikram Alva, Rachel Kolodny, and Nir Ben-Tal

PNAS March 3, 2020 117 (9) 4701-4709; first published February 20, 2020. https://doi.org/10.1073/pnas.1911349117
Open Access
High-resolution neutron crystallography visualizes an OH-bound resting state of a copper-containing nitrite reductase
Yohta Fukuda, Yu Hirano, Katsuhiro Kusaka, Tsuyoshi Inoue, and Taro Tamada

PNAS February 25, 2020 117 (8) 4071-4077; first published February 10, 2020. https://doi.org/10.1073/pnas.1918125117
Open Access
Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di-heptamer macromolecular assembly
- From the Cover
Xingjian Xu, Raquel Godoy-Ruiz, Kaylin A. Adipietro, Christopher Peralta, Danya Ben-Hail, Kristen M. Varney, Mary E. Cook, Braden M. Roth, Paul T. Wilder, Thomas Cleveland, Alexander Grishaev, Heather M. Neu, Sarah L. J. Michel, Wenbo Yu, Dorothy Beckett, Richard R. Rustandi, Catherine Lancaster, John W. Loughney, Adam Kristopeit, Sianny Christanti, Jessica W. Olson, Alexander D. MacKerell, Amedee des Georges, Edwin Pozharski, and David J. Weber

PNAS January 14, 2020 117 (2) 1049-1058; first published January 2, 2020. https://doi.org/10.1073/pnas.1919490117
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Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP
Tsan-Wen Lu, Jian Wu, Phillip C. Aoto, Jui-Hung Weng, Lalima G. Ahuja, Nicholas Sun, Cecilia Y. Cheng, Ping Zhang, and Susan S. Taylor

PNAS August 13, 2019 116 (33) 16347-16356; first published July 30, 2019. https://doi.org/10.1073/pnas.1906036116
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Functional assembly of nitrous oxide reductase provides insights into copper site maturation
Lin Zhang, Anja Wüst, Benedikt Prasser, Christoph Müller, and Oliver Einsle

PNAS June 25, 2019 116 (26) 12822-12827; first published June 12, 2019. https://doi.org/10.1073/pnas.1903819116
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Insight into microtubule nucleation from tubulin-capping proteins
Valérie Campanacci, Agathe Urvoas, Soraya Cantos-Fernandes, Magali Aumont-Nicaise, Ana-Andreea Arteni, Christophe Velours, Marie Valerio-Lepiniec, Birgit Dreier, Andreas Plückthun, Antoine Pilon, Christian Poüs, Philippe Minard, and Benoît Gigant

PNAS May 14, 2019 116 (20) 9859-9864; first published April 29, 2019. https://doi.org/10.1073/pnas.1813559116
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Relative interfacial cleavage energetics of protein complexes revealed by surface collisions
Sophie R. Harvey, Justin T. Seffernick, Royston S. Quintyn, Yang Song, Yue Ju, Jing Yan, Aniruddha N. Sahasrabuddhe, Andrew Norris, Mowei Zhou, Edward J. Behrman, Steffen Lindert, and Vicki H. Wysocki

PNAS April 23, 2019 116 (17) 8143-8148; first published April 3, 2019. https://doi.org/10.1073/pnas.1817632116

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