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structural biology

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Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis
Zhu Qiao, Edwin R. Lampugnani, Xin-Fu Yan, Ghazanfar Abbas Khan, Wuan Geok Saw, Patrick Hannah, Feng Qian, Jacob Calabria, Yansong Miao, Gerhard Grüber, Staffan Persson, and Yong-Gui Gao

PNAS March 16, 2021 118 (11) e2024015118; https://doi.org/10.1073/pnas.2024015118
Open Access
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP
Katerina Naydenova, Kyle W. Muir, Long-Fei Wu, Ziguo Zhang, Francesca Coscia, Mathew J. Peet, Pablo Castro-Hartmann, Pu Qian, Kasim Sader, Kyle Dent, Dari Kimanius, John D. Sutherland, Jan Löwe, David Barford, and Christopher J. Russo

PNAS February 16, 2021 118 (7) e2021946118; https://doi.org/10.1073/pnas.2021946118
Open Access
Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
Łukasz F. Sobala, Pearl Z. Fernandes, Zalihe Hakki, Andrew J. Thompson, Jonathon D. Howe, Michelle Hill, Nicole Zitzmann, Scott Davies, Zania Stamataki, Terry D. Butters, Dominic S. Alonzi, Spencer J. Williams, and Gideon J. Davies

PNAS November 24, 2020 117 (47) 29595-29601; first published November 5, 2020. https://doi.org/10.1073/pnas.2013620117
Open Access
Cyclic peptides can engage a single binding pocket through highly divergent modes
Karishma Patel, Louise J. Walport, James L. Walshe, Paul D. Solomon, Jason K. K. Low, Daniel H. Tran, Kevork S. Mouradian, Ana P. G. Silva, Lorna Wilkinson-White, Alexander Norman, Charlotte Franck, Jacqueline M. Matthews, J. Mitchell Guss, Richard J. Payne, Toby Passioura, Hiroaki Suga, and Joel P. Mackay

PNAS October 27, 2020 117 (43) 26728-26738; first published October 12, 2020. https://doi.org/10.1073/pnas.2003086117
Open Access
Acetylated histone H4 tail enhances histone H3 tail acetylation by altering their mutual dynamics in the nucleosome
Ayako Furukawa, Masatoshi Wakamori, Yasuhiro Arimura, Hideaki Ohtomo, Yasuo Tsunaka, Hitoshi Kurumizaka, Takashi Umehara, and Yoshifumi Nishimura

PNAS August 18, 2020 117 (33) 19661-19663; first published August 3, 2020. https://doi.org/10.1073/pnas.2010506117
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Cryo-EM analysis of a membrane protein embedded in the liposome
Xia Yao, Xiao Fan, and Nieng Yan

PNAS August 4, 2020 117 (31) 18497-18503; first published July 17, 2020. https://doi.org/10.1073/pnas.2009385117
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Disruption of evolutionarily correlated tRNA elements impairs accurate decoding
Ha An Nguyen, S. Sunita, and Christine M. Dunham

PNAS July 14, 2020 117 (28) 16333-16338; first published June 29, 2020. https://doi.org/10.1073/pnas.2004170117
Open Access
Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex
Tomas Malinauskas, Tina V. Peer, Benjamin Bishop, Thomas D. Mueller, and Christian Siebold

PNAS July 7, 2020 117 (27) 15620-15631; first published June 23, 2020. https://doi.org/10.1073/pnas.2000561117
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Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel
Haidai Hu, Rebecca J. Howard, Ugo Bastolla, Erik Lindahl, and Marc Delarue

PNAS June 16, 2020 117 (24) 13437-13446; first published June 1, 2020. https://doi.org/10.1073/pnas.1922701117
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Structural basis of nanobody recognition of grapevine fanleaf virus and of virus resistance loss
Igor Orlov, Caroline Hemmer, Léa Ackerer, Bernard Lorber, Ahmed Ghannam, Vianney Poignavent, Kamal Hleibieh, Claude Sauter, Corinne Schmitt-Keichinger, Lorène Belval, Jean-Michel Hily, Aurélie Marmonier, Véronique Komar, Sophie Gersch, Pascale Schellenberger, Patrick Bron, Emmanuelle Vigne, Serge Muyldermans, Olivier Lemaire, Gérard Demangeat, Christophe Ritzenthaler, and Bruno P. Klaholz

PNAS May 19, 2020 117 (20) 10848-10855; first published May 5, 2020. https://doi.org/10.1073/pnas.1913681117

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