New Research In

T cell

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Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies
Spencer C. Wei, Nana-Ama A. S. Anang, Roshan Sharma, Miles C. Andrews, Alexandre Reuben, Jacob H. Levine, Alexandria P. Cogdill, James J. Mancuso, Jennifer A. Wargo, Dana Pe’er, and James P. Allison

PNAS November 5, 2019 116 (45) 22699-22709; first published October 21, 2019. https://doi.org/10.1073/pnas.1821218116
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Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation
Xiaoli Wang, Sytse J. Piersma, Jabari I. Elliott, John M. Errico, Maria D. Gainey, Liping Yang, Christopher A. Nelson, Wayne M. Yokoyama, and Daved H. Fremont

PNAS October 15, 2019 116 (42) 21113-21119; first published October 1, 2019. https://doi.org/10.1073/pnas.1909414116
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T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces
Weiyang Jin, Fella Tamzalit, Parthiv Kant Chaudhuri, Charles T. Black, Morgan Huse, and Lance C. Kam

PNAS October 1, 2019 116 (40) 19835-19840; first published September 16, 2019. https://doi.org/10.1073/pnas.1906986116
Open Access
Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis
Cory M. Willis, Alexandra M. Nicaise, Antoine Menoret, Jae Kyu Ryu, Andrew S. Mendiola, Evan R. Jellison, Maria I. Givogri, David K. Han, Ernesto R. Bongarzone, Katerina Akassoglou, Anthony T. Vella, and Stephen J. Crocker

PNAS May 21, 2019 116 (21) 10488-10493; first published May 8, 2019. https://doi.org/10.1073/pnas.1816911116
Open Access
Select sequencing of clonally expanded CD8⁺ T cells reveals limits to clonal expansion
Huang Huang, Michael J. Sikora, Saiful Islam, Roshni Roy Chowdhury, Yueh-hsiu Chien, Thomas J. Scriba, Mark M. Davis, and Lars M. Steinmetz

PNAS April 30, 2019 116 (18) 8995-9001; first published April 16, 2019. https://doi.org/10.1073/pnas.1902649116
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Biphasic mechanosensitivity of T cell receptor-mediated spreading of lymphocytes
Astrid Wahl, Céline Dinet, Pierre Dillard, Aya Nassereddine, Pierre-Henri Puech, Laurent Limozin, and Kheya Sengupta

PNAS March 26, 2019 116 (13) 5908-5913; first published March 8, 2019. https://doi.org/10.1073/pnas.1811516116
Open Access
CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function
Esther Bandala-Sanchez, Naiara G. Bediaga, Ethan D. Goddard-Borger, Katrina Ngui, Gaetano Naselli, Natalie L. Stone, Alana M. Neale, Lesley A. Pearce, Ahmad Wardak, Peter Czabotar, Thomas Haselhorst, Andrea Maggioni, Lauren A. Hartley-Tassell, Timothy E. Adams, and Leonard C. Harrison

PNAS July 24, 2018 115 (30) 7783-7788; first published July 11, 2018. https://doi.org/10.1073/pnas.1722056115
Open Access
Thymic involution and rising disease incidence with age
Sam Palmer, Luca Albergante, Clare C. Blackburn, and T. J. Newman

PNAS February 20, 2018 115 (8) 1883-1888; first published February 5, 2018. https://doi.org/10.1073/pnas.1714478115
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Reply to Jiménez-Alonso et al., Schooling and Zhao, and Mortazavi: Further discussion on the immunological model of carcinogenesis
- May 08, 2018
Open Access
In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
Uma S. Gautam, Taylor W. Foreman, Allison N. Bucsan, Ashley V. Veatch, Xavier Alvarez, Toidi Adekambi, Nadia A. Golden, Kaylee M. Gentry, Lara A. Doyle-Meyers, Kasi E. Russell-Lodrigue, Peter J. Didier, James L. Blanchard, K. Gus Kousoulas, Andrew A. Lackner, Daniel Kalman, Jyothi Rengarajan, Shabaana A. Khader, Deepak Kaushal, and Smriti Mehra

PNAS January 2, 2018 115 (1) E62-E71; first published December 18, 2017. https://doi.org/10.1073/pnas.1711373114
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Localized CD47 blockade enhances immunotherapy for murine melanoma
Jessica R. Ingram, Olga S. Blomberg, Jonathan T. Sockolosky, Lestat Ali, Florian I. Schmidt, Novalia Pishesha, Camilo Espinosa, Stephanie K. Dougan, K. Christopher Garcia, Hidde L. Ploegh, and Michael Dougan

PNAS September 19, 2017 114 (38) 10184-10189; first published September 5, 2017. https://doi.org/10.1073/pnas.1710776114

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