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T cell

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TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function
Letitia Yang, Burhan Jama, Huawei Wang, Lara Labarta-Bajo, Elina I. Zúñiga, and Gerald P. Morris

PNAS December 22, 2020 117 (51) 32574-32583; first published December 7, 2020. https://doi.org/10.1073/pnas.2013188117
Open Access
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells
Eliza Mari Kwesi-Maliepaard, Muhammad Assad Aslam, Mir Farshid Alemdehy, Teun van den Brand, Chelsea McLean, Hanneke Vlaming, Tibor van Welsem, Tessy Korthout, Cesare Lancini, Sjoerd Hendriks, Tomasz Ahrends, Dieke van Dinther, Joke M. M. den Haan, Jannie Borst, Elzo de Wit, Fred van Leeuwen, and Heinz Jacobs

PNAS August 25, 2020 117 (34) 20706-20716; first published August 6, 2020. https://doi.org/10.1073/pnas.1920372117
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Bacterial immunotherapy for cancer induces CD4-dependent tumor-specific immunity through tumor-intrinsic interferon-γ signaling
Anthony C. Antonelli, Anna Binyamin, Tobias M. Hohl, Michael S. Glickman, and Gil Redelman-Sidi

PNAS August 4, 2020 117 (31) 18627-18637; first published July 17, 2020. https://doi.org/10.1073/pnas.2004421117
Open Access
Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia
Adam J. Lamble, Yoko Kosaka, Ted Laderas, Allie Maffit, Andy Kaempf, Lauren K. Brady, Weiwei Wang, Nicola Long, Jennifer N. Saultz, Motomi Mori, David Soong, Clare V. LeFave, Fei Huang, Homer Adams III, Marc M. Loriaux, Cristina E. Tognon, Pierrette Lo, Jeffrey W. Tyner, Guang Fan, Shannon K. McWeeney, Brian J. Druker, and Evan F. Lind

PNAS June 23, 2020 117 (25) 14331-14341; first published June 8, 2020. https://doi.org/10.1073/pnas.1916206117
Open Access
T_RM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection
- From the Cover
Emma C. Reilly, Kris Lambert Emo, Patrick M. Buckley, Nicholas S. Reilly, Ian Smith, Francisco A. Chaves, Hongmei Yang, Patrick W. Oakes, and David J. Topham

PNAS June 2, 2020 117 (22) 12306-12314; first published May 21, 2020. https://doi.org/10.1073/pnas.1915681117
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Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunity
Alexander H. Morrison, Mark S. Diamond, Ceire A. Hay, Katelyn T. Byrne, and Robert H. Vonderheide

PNAS April 7, 2020 117 (14) 8022-8031; first published March 25, 2020. https://doi.org/10.1073/pnas.1918971117
Open Access
Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread
Dejan Mesner, Dominik Hotter, Frank Kirchhoff, and Clare Jolly

PNAS March 31, 2020 117 (13) 7382-7391; first published March 16, 2020. https://doi.org/10.1073/pnas.1921135117
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Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing
Fella Tamzalit, Diana Tran, Weiyang Jin, Vitaly Boyko, Hisham Bazzi, Ariella Kepecs, Lance C. Kam, Kathryn V. Anderson, and Morgan Huse

PNAS February 25, 2020 117 (8) 4310-4319; first published February 10, 2020. https://doi.org/10.1073/pnas.1913220117
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Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain
Rebekka Schairer, Gareth Hall, Ming Zhang, Richard Cowan, Roberta Baravalle, Frederick W. Muskett, Peter J. Coombs, Chido Mpamhanga, Lisa R. Hale, Barbara Saxty, Justyna Iwaszkiewicz, Chantal Décaillet, Mai Perroud, Mark D. Carr, and Margot Thome

PNAS February 11, 2020 117 (6) 3093-3102; first published January 24, 2020. https://doi.org/10.1073/pnas.1912681117
Open Access
Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies
Spencer C. Wei, Nana-Ama A. S. Anang, Roshan Sharma, Miles C. Andrews, Alexandre Reuben, Jacob H. Levine, Alexandria P. Cogdill, James J. Mancuso, Jennifer A. Wargo, Dana Pe’er, and James P. Allison

PNAS November 5, 2019 116 (45) 22699-22709; first published October 21, 2019. https://doi.org/10.1073/pnas.1821218116

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