New Research In

T cell

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Radiotherapy transiently reduces the sensitivity of cancer cells to lymphocyte cytotoxicity
Karoliina Tuomela, Debayan Mukherjee, Ashley R. Ambrose, Ashish Harikrishnan, Holly Mole, Adam Hurlstone, Björn Önfelt, Jamie Honeychurch, and Daniel M. Davis

PNAS January 18, 2022 119 (3) e2111900119; https://doi.org/10.1073/pnas.2111900119
Open Access
Translational targeting of inflammation and fibrosis in frozen shoulder: Molecular dissection of the T cell/IL-17A axis
Moeed Akbar, Lindsay A. N. Crowe, Michael McLean, Emma Garcia-Melchor, Lucy MacDonald, Kristyn Carter, Umberto G. Fazzi, David Martin, Angus Arthur, James H. Reilly, Iain B. McInnes, and Neal L. Millar

PNAS September 28, 2021 118 (39) e2102715118; https://doi.org/10.1073/pnas.2102715118
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B cell residency but not T cell–independent IgA switching in the gut requires innate lymphoid cells
Mingzhu Zheng, Kairui Mao, Difeng Fang, Dan Li, Jun Lyu, Dingkang Peng, Xi Chen, Nikki Cannon, Gangqing Hu, Jiajia Han, Keji Zhao, Wanjun Chen, and Jinfang Zhu

PNAS July 6, 2021 118 (27) e2106754118; https://doi.org/10.1073/pnas.2106754118
Open Access
Fever supports CD8⁺ effector T cell responses by promoting mitochondrial translation
- From the Cover
David O’Sullivan, Michal A. Stanczak, Matteo Villa, Franziska M. Uhl, Mauro Corrado, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, Nisha Rana, Joy Edwards-Hicks, Katarzyna M. Grzes, Agnieszka M. Kabat, Ryan L. Kyle, Mario Fabri, Jonathan D. Curtis, Michael D. Buck, Annette E. Patterson, Annamaria Regina, Cameron S. Field, Francesc Baixauli, Daniel J. Puleston, Edward J. Pearce, Robert Zeiser, and Erika L. Pearce

PNAS June 22, 2021 118 (25) e2023752118; https://doi.org/10.1073/pnas.2023752118
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T-cell responses to hybrid insulin peptides prior to type 1 diabetes development
Angela M. Mitchell, Aimon A. Alkanani, Kristen A. McDaniel, Laura Pyle, Kathleen Waugh, Andrea K. Steck, Maki Nakayama, Liping Yu, Peter A. Gottlieb, Marian J. Rewers, and Aaron W. Michels

PNAS February 9, 2021 118 (6) e2019129118; https://doi.org/10.1073/pnas.2019129118
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TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function
Letitia Yang, Burhan Jama, Huawei Wang, Lara Labarta-Bajo, Elina I. Zúñiga, and Gerald P. Morris

PNAS December 22, 2020 117 (51) 32574-32583; first published December 7, 2020. https://doi.org/10.1073/pnas.2013188117
Open Access
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells
Eliza Mari Kwesi-Maliepaard, Muhammad Assad Aslam, Mir Farshid Alemdehy, Teun van den Brand, Chelsea McLean, Hanneke Vlaming, Tibor van Welsem, Tessy Korthout, Cesare Lancini, Sjoerd Hendriks, Tomasz Ahrends, Dieke van Dinther, Joke M. M. den Haan, Jannie Borst, Elzo de Wit, Fred van Leeuwen, and Heinz Jacobs

PNAS August 25, 2020 117 (34) 20706-20716; first published August 6, 2020. https://doi.org/10.1073/pnas.1920372117
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Bacterial immunotherapy for cancer induces CD4-dependent tumor-specific immunity through tumor-intrinsic interferon-γ signaling
Anthony C. Antonelli, Anna Binyamin, Tobias M. Hohl, Michael S. Glickman, and Gil Redelman-Sidi

PNAS August 4, 2020 117 (31) 18627-18637; first published July 17, 2020. https://doi.org/10.1073/pnas.2004421117
Open Access
Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia
Adam J. Lamble, Yoko Kosaka, Ted Laderas, Allie Maffit, Andy Kaempf, Lauren K. Brady, Weiwei Wang, Nicola Long, Jennifer N. Saultz, Motomi Mori, David Soong, Clare V. LeFave, Fei Huang, Homer Adams III, Marc M. Loriaux, Cristina E. Tognon, Pierrette Lo, Jeffrey W. Tyner, Guang Fan, Shannon K. McWeeney, Brian J. Druker, and Evan F. Lind

PNAS June 23, 2020 117 (25) 14331-14341; first published June 8, 2020. https://doi.org/10.1073/pnas.1916206117
Open Access
T_RM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection
- From the Cover
Emma C. Reilly, Kris Lambert Emo, Patrick M. Buckley, Nicholas S. Reilly, Ian Smith, Francisco A. Chaves, Hongmei Yang, Patrick W. Oakes, and David J. Topham

PNAS June 2, 2020 117 (22) 12306-12314; first published May 21, 2020. https://doi.org/10.1073/pnas.1915681117

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