New Research In

TNF

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Identification of a brainstem locus that inhibits tumor necrosis factor
Adam M. Kressel, Tea Tsaava, Yaakov A. Levine, Eric H. Chang, Meghan E. Addorisio, Qing Chang, Barry J. Burbach, Daniela Carnevale, Giuseppe Lembo, Anthony M. Zador, Ulf Andersson, Valentin A. Pavlov, Sangeeta S. Chavan, and Kevin J. Tracey

PNAS November 24, 2020 117 (47) 29803-29810; first published November 9, 2020. https://doi.org/10.1073/pnas.2008213117
Open Access
TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes
Roman Fischer, Maksim Sendetski, Tania del Rivero, George F. Martinez, Valerie Bracchi-Ricard, Kathryn A. Swanson, Elizabeth K. Pruzinsky, Niky Delguercio, Michael J. Rosalino, Tanja Padutsch, Roland E. Kontermann, Klaus Pfizenmaier, and John R. Bethea

PNAS August 20, 2019 116 (34) 17045-17050; first published August 7, 2019. https://doi.org/10.1073/pnas.1902091116
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Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock
Anthony Orvedahl, Michael R. McAllaster, Amy Sansone, Bria F. Dunlap, Chandni Desai, Ya-Ting Wang, Dale R. Balce, Cliff J. Luke, Sanghyun Lee, Robert C. Orchard, Maxim N. Artyomov, Scott A. Handley, John G. Doench, Gary A. Silverman, and Herbert W. Virgin

PNAS August 13, 2019 116 (33) 16497-16506; first published July 25, 2019. https://doi.org/10.1073/pnas.1822157116
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Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Palak Amin, Marcus Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim, Slawomir A. Dziedzic, Huibing Wang, Vica Jean Barrett, Yasushi Ito, Matthew J. LaVoie, and Junying Yuan

PNAS June 26, 2018 115 (26) E5944-E5953; first published June 11, 2018. https://doi.org/10.1073/pnas.1806973115
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Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration
Connie A. Larsson, Sydney M. Moyer, Bin Liu, Keith A. Michel, Vinod Pant, Peirong Yang, Justin Wong, Adel K. El-Naggar, Ralf Krahe, and Guillermina Lozano

PNAS February 27, 2018 115 (9) 2198-2203; first published February 13, 2018. https://doi.org/10.1073/pnas.1719001115
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PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP
Huibing Wang, Huyan Meng, Xingyan Li, Kezhou Zhu, Kangyun Dong, Adnan K. Mookhtiar, Huiting Wei, Ying Li, Shao-Cong Sun, and Junying Yuan

PNAS November 7, 2017 114 (45) 11944-11949; first published October 23, 2017. https://doi.org/10.1073/pnas.1715742114
Open Access
Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia
Grietje Krabbe, S. Sakura Minami, Jon I. Etchegaray, Praveen Taneja, Biljana Djukic, Dimitrios Davalos, David Le, Iris Lo, Lihong Zhan, Meredith C. Reichert, Faten Sayed, Mario Merlini, Michael E. Ward, David C. Perry, Suzee E. Lee, Ana Sias, Christopher N. Parkhurst, Wen-biao Gan, Katerina Akassoglou, Bruce L. Miller, Robert V. Farese Jr., and Li Gan

PNAS May 9, 2017 114 (19) 5029-5034; first published April 24, 2017. https://doi.org/10.1073/pnas.1700477114
Open Access
Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration
Yun Dong, Roman Fischer, Petrus J. W. Naudé, Olaf Maier, Csaba Nyakas, Maëlle Duffey, Eddy A. Van der Zee, Doortje Dekens, Wanda Douwenga, Andreas Herrmann, Eric Guenzi, Roland E. Kontermann, Klaus Pfizenmaier, and Ulrich L. M. Eisel

PNAS October 25, 2016 113 (43) 12304-12309; first published October 10, 2016. https://doi.org/10.1073/pnas.1605195113
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Cell-type–restricted anti-cytokine therapy: TNF inhibition from one pathogenic source
Grigory A. Efimov, Andrei A. Kruglov, Zoya V. Khlopchatnikova, Fedor N. Rozov, Vladislav V. Mokhonov, Stefan Rose-John, Jürgen Scheller, Siamon Gordon, Martin Stacey, Marina S. Drutskaya, Sergei V. Tillib, and Sergei A. Nedospasov

PNAS March 15, 2016 113 (11) 3006-3011; first published March 2, 2016. https://doi.org/10.1073/pnas.1520175113
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IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis
Alan M. Copenhaver, Cierra N. Casson, Hieu T. Nguyen, Matthew M. Duda, and Sunny Shin

PNAS June 16, 2015 112 (24) 7557-7562; first published June 1, 2015. https://doi.org/10.1073/pnas.1501289112

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