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tolerance

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Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4
Sharon A. Sagan, Ryan C. Winger, Andrés Cruz-Herranz, Patricia A. Nelson, Sarah Hagberg, Corey N. Miller, Collin M. Spencer, Peggy P. Ho, Jeffrey L. Bennett, Michael Levy, Marc H. Levin, Alan S. Verkman, Lawrence Steinman, Ari J. Green, Mark S. Anderson, Raymond A. Sobel, and Scott S. Zamvil

PNAS December 20, 2016 113 (51) 14781-14786; first published December 8, 2016. https://doi.org/10.1073/pnas.1617859114
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Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4
Verena Schuette, Maria Embgenbroich, Thomas Ulas, Meike Welz, Jonas Schulte-Schrepping, Astrid M. Draffehn, Thomas Quast, Katharina Koch, Melanie Nehring, Jessica König, Annegret Zweynert, Frederike L. Harms, Nancy Steiner, Andreas Limmer, Irmgard Förster, Friederike Berberich-Siebelt, Percy A. Knolle, Dirk Wohlleber, Waldemar Kolanus, Marc Beyer, Joachim L. Schultze, and Sven Burgdorf

PNAS September 20, 2016 113 (38) 10649-10654; first published September 6, 2016. https://doi.org/10.1073/pnas.1605885113
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Glimpse of natural selection of long-lived T-cell clones in healthy life
Baojun Zhang, Qingzhu Jia, Cheryl Bock, Gang Chen, Haili Yu, Qingshan Ni, Ying Wan, Qijing Li, and Yuan Zhuang

PNAS August 30, 2016 113 (35) 9858-9863; first published August 17, 2016. https://doi.org/10.1073/pnas.1601634113
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Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization
Charles B. Smarr, Woon Teck Yap, Tobias P. Neef, Ryan M. Pearson, Zoe N. Hunter, Igal Ifergan, Daniel R. Getts, Paul J. Bryce, Lonnie D. Shea, and Stephen D. Miller

PNAS May 3, 2016 113 (18) 5059-5064; first published April 18, 2016. https://doi.org/10.1073/pnas.1505782113
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Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
Katrin Klocke, Shimon Sakaguchi, Rikard Holmdahl, and Kajsa Wing

PNAS April 26, 2016 113 (17) E2383-E2392; first published April 11, 2016. https://doi.org/10.1073/pnas.1603892113
Open Access
ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria
Rebecca M. Corrigan, Lauren E. Bellows, Alison Wood, and Angelika Gründling

PNAS March 22, 2016 113 (12) E1710-E1719; first published March 7, 2016. https://doi.org/10.1073/pnas.1522179113
Open Access
Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells
Maurizio Perdicchio, Juan M. Ilarregui, Marleen I. Verstege, Lenneke A. M. Cornelissen, Sjoerd T. T. Schetters, Steef Engels, Martino Ambrosini, Hakan Kalay, Henrike Veninga, Joke M. M. den Haan, Lisette A. van Berkel, Janneke N. Samsom, Paul R. Crocker, Tim Sparwasser, Luciana Berod, Juan J. Garcia-Vallejo, Yvette van Kooyk, and Wendy W. J. Unger

PNAS March 22, 2016 113 (12) 3329-3334; first published March 3, 2016. https://doi.org/10.1073/pnas.1507706113
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Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets
John F. Ryan, Rachel Hovde, Jacob Glanville, Shu-Chen Lyu, Xuhuai Ji, Sheena Gupta, Robert J. Tibshirani, David C. Jay, Scott D. Boyd, R. Sharon Chinthrajah, Mark M. Davis, Stephen J. Galli, Holden T. Maecker, and Kari C. Nadeau

PNAS March 1, 2016 113 (9) E1286-E1295; first published January 25, 2016. https://doi.org/10.1073/pnas.1520180113
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The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity
Buvana Ravishankar, Haiyun Liu, Rahul Shinde, Kapil Chaudhary, Wei Xiao, Jillian Bradley, Marianne Koritzinsky, Michael P. Madaio, and Tracy L. McGaha

PNAS August 25, 2015 112 (34) 10774-10779; first published August 10, 2015. https://doi.org/10.1073/pnas.1504276112
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γδ T cells affect IL-4 production and B-cell tolerance
Yafei Huang, Ryan A. Heiser, Thiago O. Detanico, Andrew Getahun, Greg A. Kirchenbaum, Tamara L. Casper, M. Kemal Aydintug, Simon R. Carding, Koichi Ikuta, Hua Huang, John C. Cambier, Lawrence J. Wysocki, Rebecca L. O’Brien, and Willi K. Born

PNAS January 6, 2015 112 (1) E39-E48; first published December 22, 2014. https://doi.org/10.1073/pnas.1415107111

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