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Zika virus

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Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors
Rachel P. M. Abrams, Adam Yasgar, Tadahisa Teramoto, Myoung-Hwa Lee, Dorjbal Dorjsuren, Richard T. Eastman, Nasir Malik, Alexey V. Zakharov, Wenxue Li, Muzna Bachani, Kyle Brimacombe, Joseph P. Steiner, Matthew D. Hall, Anuradha Balasubramanian, Ajit Jadhav, Radhakrishnan Padmanabhan, Anton Simeonov, and Avindra Nath

PNAS December 8, 2020 117 (49) 31365-31375; first published November 23, 2020. https://doi.org/10.1073/pnas.2005463117
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Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target
Zhenjian He, Shu An, Jiahui Chen, Shuqing Zhang, Chahui Tan, Jianchen Yu, Hengming Ye, Yun Wu, Jie Yuan, Jueheng Wu, Xun Zhu, and Mengfeng Li

PNAS September 22, 2020 117 (38) 23869-23878; first published September 9, 2020. https://doi.org/10.1073/pnas.2007773117
Open Access
A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques
Koen K. A. Van Rompay, Lark L. Coffey, Tania Kapoor, Anna Gazumyan, Rebekah I. Keesler, Andrea Jurado, Avery Peace, Marianna Agudelo, Jennifer Watanabe, Jodie Usachenko, Anil Singapuri, Ramya Immareddy, Amir Ardeshir, Jackson B. Stuart, Stylianos Bournazos, Jeffrey V. Ravetch, Paul J. Balderes, Ivo C. Lorenz, Shannon R. Esswein, Jennifer R. Keeffe, Pamela J. Bjorkman, Qiao Wang, Charles M. Rice, Margaret R. MacDonald, Michel C. Nussenzweig, and Davide F. Robbiani

PNAS April 7, 2020 117 (14) 7981-7989; first published March 24, 2020. https://doi.org/10.1073/pnas.2000414117
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Subgenomic flavivirus RNA binds the mosquito DEAD/H-box helicase ME31B and determines Zika virus transmission by Aedes aegypti
Giel P. Göertz, Joyce W. M. van Bree, Anwar Hiralal, Bas M. Fernhout, Carmen Steffens, Sjef Boeren, Tessa M. Visser, Chantal B. F. Vogels, Sandra R. Abbo, Jelke J. Fros, Constantianus J. M. Koenraadt, Monique M. van Oers, and Gorben P. Pijlman

PNAS September 17, 2019 116 (38) 19136-19144; first published September 5, 2019. https://doi.org/10.1073/pnas.1905617116
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Genome-wide CRISPR screen for Zika virus resistance in human neural cells
Yun Li, Julien Muffat, Attya Omer Javed, Heather R. Keys, Tenzin Lungjangwa, Irene Bosch, Mehreen Khan, Maria C. Virgilio, Lee Gehrke, David M. Sabatini, and Rudolf Jaenisch

PNAS May 7, 2019 116 (19) 9527-9532; first published April 24, 2019. https://doi.org/10.1073/pnas.1900867116
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Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope
Feng Long, Michael Doyle, Estefania Fernandez, Andrew S. Miller, Thomas Klose, Madhumati Sevvana, Aubrey Bryan, Edgar Davidson, Benjamin J. Doranz, Richard J. Kuhn, Michael S. Diamond, James E. Crowe Jr., and Michael G. Rossmann

PNAS January 29, 2019 116 (5) 1591-1596; first published January 14, 2019. https://doi.org/10.1073/pnas.1815432116
Open Access
Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages
Aaron F. Carlin, Edward A. Vizcarra, Emilie Branche, Karla M. Viramontes, Lester Suarez-Amaran, Klaus Ley, Sven Heinz, Christopher Benner, Sujan Shresta, and Christopher K. Glass

PNAS September 25, 2018 115 (39) E9172-E9181; first published September 11, 2018. https://doi.org/10.1073/pnas.1807690115
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Seroprevalence, risk factor, and spatial analyses of Zika virus infection after the 2016 epidemic in Managua, Nicaragua
José Victor Zambrana, Fausto Bustos Carrillo, Raquel Burger-Calderon, Damaris Collado, Nery Sanchez, Sergio Ojeda, Jairo Carey Monterrey, Miguel Plazaola, Brenda Lopez, Sonia Arguello, Douglas Elizondo, William Aviles, Josefina Coloma, Guillermina Kuan, Angel Balmaseda, Aubree Gordon, and Eva Harris

PNAS September 11, 2018 115 (37) 9294-9299; first published August 27, 2018. https://doi.org/10.1073/pnas.1804672115
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Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease
Qiang Ding, Jenna M. Gaska, Florian Douam, Lei Wei, David Kim, Metodi Balev, Brigitte Heller, and Alexander Ploss

PNAS July 3, 2018 115 (27) E6310-E6318; first published June 18, 2018. https://doi.org/10.1073/pnas.1803406115
Open Access
Implications of Zika virus and congenital Zika syndrome for the number of live births in Brazil
Marcia C. Castro, Qiuyi C. Han, Lucas R. Carvalho, Cesar G. Victora, and Giovanny V. A. França

PNAS June 12, 2018 115 (24) 6177-6182; first published May 29, 2018. https://doi.org/10.1073/pnas.1718476115

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