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Twelve patients with T cell large granular lymphocyte leukemia and associated hematocytopenia
were treated in a phase I dose-escalation trial with the murine monoclonal antibody
Mikβ1. Mikβ1 identifies CD122, the β-subunit shared by the IL-2 and IL-15 ...
The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates
cell proliferation, cytoskeletal organization, and other signaling networks, and is
the most frequent target of activating mutations in cancer. Activating germline mutations
...
The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis
(PFAPA) is the most common periodic fever disease in children. However, the pathogenesis
is unknown. Using a systems biology approach we analyzed blood samples from ...
Little is known about the potential for engraftment of autologous hematopoietic stem
cells in human adults not subjected to myeloablative conditioning regimens. Five adult
patients with the p47phox deficiency form of chronic granulomatous disease ...
Despite significant advances in the treatment of Hodgkin’s lymphoma (HL), a significant
proportion of patients will not respond or will subsequently relapse. We identified
CD25, the IL-2 receptor alpha subunit, as a favorable target for systemic ...
A number of non-human-immunodeficiency-virus (HIV) type 1 disorders are associated
with CD4+ T-cell deficiency and dysfunction. However, the etiopathogenesis of CD4+
T-cell immunodeficiency in these disease states remains unclear. Human ...
Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded
complex polyriboinosinic·polyribocytidylic acid than intact rats. They are protected
from such lethal effects by corticosterone. The complex can rapidly induce ...
A state of T-cell activation, reflected by a marked degree of spontaneous proliferation
in vitro, exists among patients with human T-cell lymphotropic virus type I (HTLV-I)-associated
myelopathy/tropical spastic paraparesis (HAM/TSP) but not in those ...
Particulate organic carbon (POC) produced in the surface ocean sinks through the water
column and is respired at depth, acting as a primary vector sequestering carbon in
the abyssal ocean. Atmospheric carbon dioxide levels are sensitive to the length (...
The cellular translational machinery (TM) synthesizes proteins using exclusively L-
or achiral aminoacyl-tRNAs (aa-tRNAs), despite the presence of D-amino acids in nature
and their ability to be aminoacylated onto tRNAs by aa-tRNA synthetases. The ...
Liver cells, isolated from either juvenile rats or chickens by a collagenase perfusion
technique, reaggregated when maintained in suspension. The cells exhibited marked
adhesive specificity; when suspensions contained both cell types, the ...
A biphasic increase of putrescine concentration occurs in rat hepatoma tissue culture
cells induced to proliferate. DL-alpha-Methyl ornithine, a competitive inhibitor of
ornithine decarboxylase ( L-ornithine carboxylyase, EC 4.1.1.7) of hepatoma tissue
...
The fracture faces of frozen rat liver mitochondria reveal that intramembrane particles
can be induced to under go long-range lateral translational motion and aggregation,
which parallel the appearance of large, particle-free smooth patches in the ...
Clonal mouse neuroblastoma cells without tyrosine 3-monooxygenase [EC 1.14.16.2; tyrosine
hydroxylase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating)]
activity were fused with normal cells from embryonic mouse sympathetic ...
We studied the effects of human plasma lipoproteins on the synthesis of prostaglandin
(PG) E2 in Swiss 3T3 mouse fibroblasts. Quiescent cells, maintained in medium deficient
in both platelet-derived growth factor (PDGF) and lipoproteins, ...
In nature, most organisms experience conditions that are suboptimal for growth. To
survive, cells must fine-tune energy-demanding metabolic processes in response to
nutrient availability. Here, we describe a novel mechanism by which protein synthesis
in ...
The amino-acid sequence of the hemebinding region of bakers' yeast cytochrome b2 [L-(+)-lactate dehydrogenase, EC 1.1.2.3] has been determined. It shows a strong
similarity with the sequence of microsomal cytochrome b5, and appears to be ...
Human hookworm infection is a major cause of gastrointestinal blood loss and iron
deficiency anemia, affecting up to one billion people in the developing world. These
soil-transmitted helminths cause blood loss during attachment to the intestinal ...
Biological productivity in the equatorial Pacific is relatively high compared with
other low-latitude regimes, especially east of the dateline, where divergence driven
by the trade winds brings nutrient-rich waters of the Equatorial Undercurrent to the
...
We report that osteopenia is a prominent and previously unappreciated clinical feature
of patients with X-linked hyper-IgM syndrome, an inherited immune deficiency disorder
caused by mutations in the gene encoding CD40 ligand (CD40L). We therefore ...